Document Detail


Chronic idiopathic thrombocytopenic purpura (ITP) in adult Ethiopians: clinical findings and response to therapy.
MedLine Citation:
PMID:  2060509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between January 1982 and December 1989, thirty four cases of chronic idiopathic thrombocytopenic purpura (ITP) were seen in adult Ethiopians in the Department of Internal Medicine in-patient and haematology referral clinic, of Tikur Anbessa teaching hospital. Twenty three were females and eleven males; female to male ratio of 2.1:1. The age range was 13-57 years, with a mean of 24.9 years. The commonest manifestations were: purpura, epistaxis, gum-bleeding and menorrhagia. The duration of symptoms ranged from one month to over ten years (median 4.5 months). The platelet counts ranged from 4000/mm3 to 77,000/mm3 (mean - 19,200/mm3), haemoglobin 3.01 to 15.4 gm/dl (mean - 8.2 gm/dl). Four (11.8%) patients were not treated; of these, one went into spontaneous remission. Thirty patients (88.2%) were treated with prednisolone 1.0 to 1.5 mg/kg/day orally. Of these, 7 (23.3%) had excellent, 2 (6.7%) good, 6 (20%) fair, and 15 (50%) had poor responses. Ten patients had splenectomy with 5 (50%) excellent 2 (20%) good, 2 (20%) fair and 1 (10%) poor response. One patient with refractory ITP was treated with immunosuppressive drugs and had an excellent response. Fifteen patients are alive and on followup 3-122 months (median 33 months) after diagnosis, fifteen are lost after followup of 1-66 months (median 9 months) and four have died 1-18 months (median 2 months) after diagnosis. Chronic ITP is frequently seen in adult Ethiopians, its clinical features and response to therapy are similar to those reported in the literature.
Authors:
M Shamebo; O Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ethiopian medical journal     Volume:  29     ISSN:  0014-1755     ISO Abbreviation:  Ethiop. Med. J.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373223     Medline TA:  Ethiop Med J     Country:  ETHIOPIA    
Other Details:
Languages:  eng     Pagination:  71-80     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Faculty of Medicine, Addis Abeba University, Ethiopia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Clinical Protocols / standards
Combined Modality Therapy
Diagnosis, Differential
Female
Humans
Immunosuppression / standards
Male
Middle Aged
Platelet Count
Prednisolone / administration & dosage,  therapeutic use
Purpura, Thrombocytopenic / blood,  diagnosis,  therapy*
Splenectomy / standards
Chemical
Reg. No./Substance:
50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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