| Chronic hypoxia: a model for cyanotic congenital heart defects. | |
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MedLine Citation:
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PMID: 12091815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The postoperative course of cyanotic children is generally more complicated than that of acyanotic children. A possible reason is reoxygenation injury at the beginning of cardiopulmonary bypass. In this study we tested the hypothesis that reoxygenation of chronically hypoxic hearts is worse than that of normoxic hearts. METHODS: Two groups of rats (n = 9 each) were exposed to either room air (fraction of inspired oxygen, 0.21%) or chronic hypoxia (fraction of inspired oxygen, 0.10%) for 2 weeks. Hearts were then isolated and perfused for 30 minutes with hypoxic buffer (oxygen saturation, 10%), followed by 30 minutes of reoxygenation (oxygen saturation, 100%). RESULTS: In hypoxic rats hematocrit values, hemoglobin concentrations, and red cells were higher (69% +/- 6% vs 40% +/- 6%, 219 +/- 14 vs 124 +/- 12 g/L, and 10.30 +/- 0.6 vs 6.32 +/- 0.5/microL/1000, respectively; P <.0001); the amount of ingested food was less (22.3 +/- 4.8 vs 30.7 +/- 3.9 g/d, P <.001), as was the amount of ingested water (21.0 +/- 3.1 vs 50.4 +/- 14.6 mL/d, P <.0001); and body weight was lower (182 +/- 14.2 vs 351 +/- 40.1 g, P <.0001), as was heart weight (1107 +/- 119 vs 1312 +/- 128 mg, P <.005). The heart weight/body weight ratio was higher (6.10 +/- 0.8 vs 3.74 +/- 0.1 mg/g, P <.0001). Systolic and diastolic functions, not different during the hypoxic baseline period, were more impaired in hypoxic than in normoxic hearts after the reoxygenation, whereas coronary resistance remained lower. During the hypoxic perfusion, the venous partial pressure of oxygen remained low in both groups, whereas during reoxygenation, partial pressure of oxygen was higher in hypoxic hearts, with a lower (P <.01) oxygen uptake. During hypoxic baseline adenosine triphosphate turnover, lactate production and lactate turnover were lower in hypoxic hearts (P <.005, P <.0001, and P <.0001, respectively). CONCLUSIONS: Body and blood values are severely affected by chronic hypoxia, and the cardiac effects of uncontrolled reoxygenation after chronic hypoxia are more severe than after acute hypoxia. |
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Authors:
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Antonio F Corno; Giuseppina Milano; Michele Samaja; Piergiorgio Tozzi; Ludwig K von Segesser |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 124 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-01 Completed Date: 2002-08-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 105-12 Citation Subset: AIM; IM |
Affiliation:
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Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Antonio.Corno@chuv.hospvd.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Anoxia / physiopathology* Cardiopulmonary Bypass* Chronic Disease Cyanosis / physiopathology Disease Models, Animal Heart Defects, Congenital / surgery* Hemodynamics / physiology Lactic Acid / metabolism Male Myocardial Reperfusion Injury / physiopathology* Myocardium / metabolism Oxygen Consumption Perfusion Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate |
| Comments/Corrections | |
Comment In:
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J Thorac Cardiovasc Surg. 2002 Jul;124(1):16-9
[PMID:
12091803
]
J Thorac Cardiovasc Surg. 2002 Jul;124(1):14-5 [PMID: 12091802 ] |
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