| Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats. | |
| | |
MedLine Citation:
|
PMID: 22285933 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Stress during pregnancy is known to have a significant impact on animal's behavior and offspring development. The effects of gestational hypoxia on maternal behavior have not been studied. In the present study, we investigated the effects of gestational hypoxia exposure on dam's maternal behavior, offspring's growth and plasma corticosterone levels after parturition in rats. Altitude hypoxia (3 and 5km) was simulated in the hypobaric chambers during the last week of pregnancy and the effects were compared to those found in controls exposed at sea level. We found that gestational hypoxia significantly decreased dam's arched-back nursing activity across the lactation period. The effect was more profound in 5km group. Gestational hypoxia also altered other maternal behaviors such as blanket and passive nursing. Hypoxia exposure was associated with abnormal birth weight and postnatal growth in pups, with a significantly higher and lower birth weight than control found in 3 and 5km groups, respectively, and accelerated growth in both stressed groups. Gestational hypoxia exposure significantly elevated plasma corticosterone levels in dams at the time of weaning and in pups across the measurement days. Taken together, the present results indicate that hypoxia, particularly severe hypoxia during the late phase of pregnancy has a significantly adverse impact on animal's behavior, endocrine function and offspring development. The higher birth weight found in the offspring of 3km group suggests a compensatory system counteracting with the inhibitory effects of hypoxia on fetus growth at this altitude. |
| | |
Authors:
|
Fang Chen; Shouyang Du; Jianghui Bian; Zhi-Bing You; Yan Wu |
Related Documents
:
|
7367813 - Urinary excretion of position isomers type iii in normal man and a series of different ... 17145363 - Pregnancy and urinary diversion. 19375703 - Expectant management of pregnancy-related high-velocity uterine arteriovenous shunt dia... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-21 |
Journal Detail:
|
Title: Hormones and behavior Volume: - ISSN: 1095-6867 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
College of Life and Environmental Sciences, Hangzhou Normal University, 16 Xuelin Street, Xiasha High Education Area, Hangzhou 310036, Zhejiang, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Are PPAR alpha agonists a rational therapeutic strategy for preventing abnormalities of the diabetic...
Next Document: Oxytocin and social affiliation in humans.