Document Detail

Chronic hypoxia differentially alters the responses of pulmonary arteries and veins to endothelin-1 and other agents.
MedLine Citation:
PMID:  10355589     Owner:  NLM     Status:  MEDLINE    
The effects of chronic hypoxia on the responses of rat large pulmonary arteries and veins to vasoactive agents have been examined. Endothelin-1-induced contractions of pulmonary arteries and pulmonary veins were reduced by chronic hypoxia. In contrast, chronic hypoxia augmented sarafotoxin 6c-induced contractile responses in pulmonary veins but not in pulmonary arteries. Chronic hypoxia augmented the constrictor effect of phenylephrine in pulmonary arteries, but not in pulmonary veins. The thromboxane receptor agonist, U46619 (9,11-dideoxy-9alpha,11alpha-epoxy-methanoprostaglandin++ + f2alpha) contracted pulmonary arteries and pulmonary veins, and although maximal responses were not altered in chronically hypoxic preparations, the EC50 value in pulmonary arteries was increased following chronic hypoxia. The relaxant effects of acetylcholine and isoprenaline on pulmonary arteries were potentiated by chronic hypoxia. In contrast, ionomycin-mediated relaxations of pulmonary arteries and pulmonary veins were reduced, while sodium nitroprusside-induced relaxation of pulmonary arteries and veins were not altered by chronic hypoxia. Previous studied have looked primarily at the effects of chronic hypoxia on pulmonary arteries. This data provides evidence that chronic hypoxia also causes selective changes in the reactivity of large pulmonary veins.
H Lal; K I Williams; B Woodward
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  371     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-30     Completed Date:  1999-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  11-21     Citation Subset:  IM    
Department of Pharmacy and Pharmacology, University of Bath, UK.
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MeSH Terms
Anoxia / physiopathology*
Endothelin-1 / pharmacology*
Hypertrophy, Right Ventricular / etiology
Pulmonary Artery / drug effects*
Pulmonary Veins / drug effects*
Rats, Wistar
Time Factors
Vasoconstriction / drug effects*
Vasodilation / drug effects*
Reg. No./Substance:

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