Document Detail

Chronic hypoxia alters fatty acid composition of phospholipids in right and left ventricular myocardium.
MedLine Citation:
PMID:  12030379     Owner:  NLM     Status:  MEDLINE    
Adult male Wistar rats were exposed to intermittent high altitude hypoxia of 7000 m simulated in a hypobaric chamber for 8 h/day, 5 days a week; the total number of exposures was 25. The concentration of individual phospholipids and their fatty acid (FA) profile was determined in right (RV) and left (LV) ventricles. Adaptation to hypoxia decreased the concentration of diphosphatidytglycerol (DPG) in hypertrophied RV by 19% and in non-hypertrophied LV by 12% in comparison with normoxic controls. Chronically hypoxic hearts exhibited lower phospholipid n-6 polyunsaturated FA(PUFA) content mainly due to decreased linoleic acid (18:2n-6), which was opposed by increased n-3 PUFA mainly due to docosahexaenoic acid (22:6n-3) in phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI). The content of arachidonic acid (20:4n-6) was unchanged in total phospholipids, but in PC it was increased in both ventricles (by 22%) and in PE decreased in LV only (by 20%). Chronic hypoxia increased the un-saturation index of PC and PE in both ventricles. The content of monounsaturated FA (MUFA) was increased and 18:2n-6 decreased in DPG. The proportion of saturated FA was increased in PC and PI of hypoxic RV but not LV. The FA composition of phosphatidylserine was not altered in hypoxic ventricles. It is concluded that chronic hypoxia led to only minor changes in individual phospholipid concentration in rat ventricular myocardium, but markedly altered their FA profile. These changes, in particular the greater incorporation of n-3 PUFA into phospholipids and increased un-saturation index, may lead to a better preservation of membrane integrity and thereby contribute to improved ischemic tolerance of chronically hypoxic hearts.
Jana Jezková; Olga Nováková; Frantisek Kolár; Eva Tvrzická; Jan Neckár; Frantisek Novák
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  232     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-27     Completed Date:  2003-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Faculty of Science, Academy of Sciences of the Czech republic and Centre for experiment al Cardiovascular Research, Prague.
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MeSH Terms
Adaptation, Physiological
Altitude Sickness / physiopathology
Anoxia / physiopathology*
Body Weight
Chronic Disease
Fatty Acids / analysis*,  metabolism
Heart Ventricles / chemistry*,  metabolism
Organ Size
Phospholipids / chemistry*,  metabolism
Rats, Wistar
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids

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