Document Detail


Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep.
MedLine Citation:
PMID:  9541746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal hypoxia is an important cause of neurologic morbidity and mortality. Hypoxia-induced increase in extracellular glutamate concentration can lead to excitotoxic neuronal death in adults. The objective of this study was to test whether chronic fetal hypoxemia increases extracellular glutamate concentration in the unanesthetized intact cerebral cortex of the near-term fetal sheep. Microdialysis probes were implanted into the parasagittal parietal cortex and periventricular white matter of near-term fetal sheep. At 124 +/- 1 days of gestation, extracellular glutamate concentration was determined before and during 24 h of fetal hypoxemia. Chronic hypoxemia was produced by tightening a vascular occluder placed around the maternal common iliac artery. Larger decreases in fetal arterial oxygen content were associated with larger increases in extracellular glutamate concentration in the parietal cortex (Kendall's tau = 0.81, N = 7, p = 0.005). No such relationship was detected in the periventricular white matter. Chronic hypoxemia increases extracellular glutamate concentration in the intact cerebral cortex of the unanesthetized near-term fetal sheep.
Authors:
J L Henderson; J D Reynolds; F Dexter; B Atkins; J Hrdy; D Poduska; D H Penning
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  105     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Iowa, College of Medicine, Iowa City, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / metabolism*,  physiopathology
Blood Gas Analysis
Cerebral Cortex / embryology,  metabolism*
Chronic Disease
Extracellular Space / metabolism
Female
Fetal Hypoxia / metabolism*,  physiopathology
Glutamic Acid / metabolism*
Hemodynamics / physiology
Pregnancy
Sheep
Grant Support
ID/Acronym/Agency:
1RO1NS34457-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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