Document Detail

Chronic hypovolemia associated with accelerated hypertension and orthostatic hypotension in a patient on continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  1292347     Owner:  NLM     Status:  MEDLINE    
We report a patient with nondiabetic end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD) associated with chronic hypovolemia. Despite the administration of nilvadipine, the patient showed accelerated hypertension and concomitantly orthostatic hypotension. Plasma renin activity was markedly high, and blockade of angiotensin II action by captopril or an angiotension II antagonist decreased the supine blood pressure. This indicated that the enhanced activity of the renin-angiotensin system was the principal cause of the supine hypertension. The plasma concentration of norepinephrine was also very high. After correction of hypovolemia by blood transfusion, the enhancement of the renin-angiotensin system and high plasma norepinephrine level were reduced, and symptomatic orthostatic hypotension disappeared. The accelerated hypertension was easily controlled by the administration of low-dose captopril and nilvadipine. These findings suggest that chronic hypovolemia related to the intractable supine hypertension as well as orthostatic hypotension. Hypovolemia-induced enhancement of the renin-angiotensin system and sympathetic nerve activity may cause vasoconstrictive hypertension in patients on CAPD.
T Touma; H Muratani; K Iseki; N Kawazoe; S Takishita; K Fukiyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of nephrology     Volume:  12     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1992  
Date Detail:
Created Date:  1993-03-29     Completed Date:  1993-03-29     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
Third Department of Internal Medicine, School of Medicine, University of The Ryukyus, Okinawa, Japan.
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MeSH Terms
Blood Volume*
Hypertension, Renal / complications*,  physiopathology
Hypotension, Orthostatic / complications*
Kidney Failure, Chronic / complications,  physiopathology,  therapy
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Renin-Angiotensin System / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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