Document Detail


Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius.
MedLine Citation:
PMID:  17145979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microinjection of the inhibitory neurotransmitter gamma-aminobutyric acid B-subtype receptor agonist baclofen into the nucleus tractus solitarius increases arterial blood pressure and sympathetic nerve discharge. The baclofen-induced pressor response is enhanced in chronic hypertension. We hypothesized that a postsynaptic mechanism contributes to the enhanced responses to baclofen in hypertension. We investigated the postsynaptic effect of baclofen on second-order baroreceptor neurons, identified by 1,1'-dilinoleyl-3,3,3',3'-tetra-methylindocarbocyanine, 4-chlorobenzenesulphonate labeling of the aortic nerve, in nucleus tractus solitarius slices from sham-operated normotensive and unilateral nephrectomized, renal-wrap hypertensive rats. After 4 weeks, arterial blood pressure was 153+/-7 mm Hg in hypertensive rats (n=9) and 93+/-3 mm Hg in normotensive rats (n=8; P<0.05). There was no difference in resting membrane potential (54.5+/-0.7 versus 53.3+/-0.6 mV) or input resistance (1.07+/-0.11 versus 1.03+/-0.11 GOmega) between hypertensive and normotensive neurons (both n=18). Baclofen induced a net outward current in nucleus tractus solitarius neurons in the presence of 1 micromol/L tetrodotoxin. The EC50 of the baclofen effect was greater in normotensive cells (9.1+/-3.2 micromol/L; n=5) than hypertensive cells (3.0+/-0.5 micromol/L; n=7; P<0.05), and baclofen (10 micromol/L) induced a greater decrease in input resistance in hypertensive cells (61+/-2%; n=6) than in normotensive cells (45+/-4%; n=9; P<0.05). Both potassium and calcium channels were involved in the baclofen-evoked whole-cell current. The results suggest an enhanced postsynaptic response to activation of inhibitory neurotransmitter gamma-aminobutyric acid B-subtype receptors in second-order baroreceptor neurons in the nucleus tractus solitarius in renal-wrap hypertensive rats. This enhanced inhibition could alter baroreflex function in chronic hypertension.
Authors:
Weirong Zhang; Myrna Herrera-Rosales; Steve Mifflin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-12-04
Journal Detail:
Title:  Hypertension     Volume:  49     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-03-06     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  659-63     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baclofen / pharmacology*
Chronic Disease
Disease Models, Animal
GABA Agonists / pharmacology*
Hypertension / physiopathology*
Male
Neurons / drug effects
Pressoreceptors / drug effects
Rats
Rats, Sprague-Dawley
Solitary Nucleus / drug effects*
Synaptic Transmission / drug effects*
Grant Support
ID/Acronym/Agency:
HL-56637/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/GABA Agonists; 1134-47-0/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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