Document Detail

Chronic hydrocephalus in adults.
MedLine Citation:
PMID:  15446589     Owner:  NLM     Status:  MEDLINE    
Chronic hydrocephalus is a complex condition, the incidence of which increases with increasing age. It is characterised by the presence of ventricular enlargement in the absence of significant elevations of intracranial pressure. The clinical syndrome may develop either as a result of decompensation of a "compensated" congenital hydrocephalus, or it may arise de novo in adult life secondary to a known acquired disturbance of normal CSF dynamics. The latter may be due to late onset acqueductal stenosis or disruption of normal CSF absorptive pathways following subarachnoid hemorrhage or meningitis ("secondary" normal pressure hydrocephalus (NPH)). In some cases the cause of the hydrocephalus remains obscure ("idiopathic" NPH). In all forms of chronic hydrocephalus the clinical course of the disease is heavily influenced by changes in the brain associated with aging, in particular cerebrovascular disease. Recent research has challenged previously held tenets regarding the CSF circulatory system and this in turn has led to a radical rethinking of the pathophysiological basis of chronic hydrocephalus.
Richard J Edwards; Stephen M Dombrowski; Mark G Luciano; Ian K Pople
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  14     ISSN:  1015-6305     ISO Abbreviation:  Brain Pathol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2004-10-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  325-36     Citation Subset:  IM    
Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom.
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MeSH Terms
Brain / pathology*
Cerebrospinal Fluid / metabolism
Chronic Disease
Hydrocephalus / etiology*,  pathology*,  physiopathology*
Ventriculoperitoneal Shunt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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