Document Detail

Chronic hind limb ischemia reduces myocardial ischemia-reperfusion injury in the rabbit heart by promoting coronary angiogenesis/arteriogenesis.
MedLine Citation:
PMID:  20363986     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIM: Application of ischemic injury in a remote organ may provide protection of other tissues against ischemia. We hypothesized that ischemia in the rabbit hind limb protects against myocardial ischemia by increasing angiogenesis/arteriogenesis. MATERIALS AND METHODS: In the first experiment, severe limb ischemia (LI) was induced in 26 New Zealand White rabbits by excision of the femoral artery while another 26 served as controls (no ischemia; sham operation [SHO]). Four weeks later, the blood vessels of the subendocardial and intramyocardial areas of the excised hearts were counted. In the second experiment, 14 LI rabbits and 14 SHO controls were subjected to 30 min of regional heart ischemia and 3 h reperfusion. Infarct size and the areas-at-risk were determined. RESULTS: Compared with controls, LI rabbits showed more subendocardial (103+/-14 vs. 113+/-13 capillaries/mm2, respectively; p=0.01) and intramyocardial blood vessels (102+/-12 vs. 114+/-16 capillaries/mm(2), respectively; p=0.009). LI rabbits had significantly smaller infarct size compared with the SHO animals (infarct areas/areas-at-risk: 14.37+/-11.23% vs. 31.31+/-13.73%, respectively; p=0.003). CONCLUSION: Chronic hind LI reduces myocardial infarct size by promoting coronary angiogenesis/arteriogenesis in an experimental model.
Varnavas C Varnavas; Kosmas I Paraskevas; Efstathios K Iliodromitis; Anastasia Zoga; Irini Glava; Loukas Kaklamanis; John Spartinos; Theodore Lyras; Dimitrios T Kremastinos; Dimitri P Mikhailidis; Zenon S Kyriakides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  24     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Second Department of Cardiology, Red Cross Hospital, Athens 115 26, Greece.
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MeSH Terms
Chronic Disease
Coronary Circulation / physiology
Hindlimb / blood supply*
Ischemia / pathology,  physiopathology*
Ischemic Preconditioning / methods*
Muscular Atrophy / physiopathology
Myocardial Infarction / pathology,  physiopathology,  prevention & control
Myocardial Reperfusion Injury / pathology,  physiopathology,  prevention & control*
Myocardium / pathology
Neovascularization, Physiologic / physiology*

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