| Chronic high fat, high cholesterol supplementation decreases 18 kDa Translocator Protein binding capacity in association with increased oxidative stress in rat liver and aorta. | |
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MedLine Citation:
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PMID: 20060027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well known that high fat and high cholesterol levels present a contributing factor to pathologies including fatty liver and atherosclerosis. Oxidative stress is also considered to play a role in these pathologies. The 18 kDa Translocator Protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is known to be involved in cholesterol metabolism, oxidative stress, and cardiovascular pathology. We applied a high fat high cholesterol atherogenic (HFHC) diet to rats to study correlations between cardiovascular and liver pathology, oxidative stress, and TSPO expression in the liver and the cardiovascular system. This study corroborates the presence of increased oxidative stress markers and decreased anti-oxidants in liver and aorta. In addition, it appeared that induction of oxidative stress in the liver and aorta by atherogenic HFHC diet was accompanied by a reduction in TSPO binding density in both these tissues. Our data suggest that involvement of TSPO in oxidative stress and ROS generation, as reported in other studies, may also take part in atherogenesis as induced by HFHC diet. Presently, it is not clear whether this TSPO response is compensatory for the stress induced by HFHC diet or is a participant in the induction of oxidative stress. |
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Authors:
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Jasmina Dimitrova-Shumkovska; Leo Veenman; Trpe Ristoski; Svetlana Leschiner; Moshe Gavish |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-06 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 910-21 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biochemistry and Physiology, Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss Cyril and Methodius University, Gazi Baba bb PO Box 162, 1000 Skopje, The Former Yugoslav Republic of Macedonia. jasminad@iunona.pmf.ukim.edu.mk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Aorta, Thoracic / drug effects, metabolism*, pathology Biological Markers Cardiovascular Diseases / chemically induced, metabolism, pathology Carrier Proteins / metabolism* Cholesterol, Dietary / adverse effects* Diet Diet, Atherogenic Dietary Fats / adverse effects* Endothelium, Vascular / pathology Glycosylation End Products, Advanced / metabolism Liver / drug effects, metabolism*, pathology Male Oxidation-Reduction Oxidative Stress / drug effects* Protein Carbonylation / drug effects Rats Rats, Wistar Receptors, GABA-A / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Carrier Proteins; 0/Cholesterol, Dietary; 0/Dietary Fats; 0/Glycosylation End Products, Advanced; 0/Receptors, GABA-A; 141440-82-6/Bzrp protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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