Document Detail

Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats.
MedLine Citation:
PMID:  20406669     Owner:  NLM     Status:  MEDLINE    
Adult neurogenesis in the dentate gyrus of the hippocampus is altered with stress exposure and has been implicated in depression. High levels of corticosterone (CORT) suppress neurogenesis in the dentate gyrus of male rats. However both acute and chronic stress do not consistently reduce adult hippocampal neurogenesis in female rats. Therefore, this study was conducted to investigate the effect of different doses of corticosterone on hippocampal neurogenesis in male and female rats. Rats received 21 days of s.c. injections of either oil, 10 or 40 mg/kg CORT. Subjects were perfused 24 h after the last CORT injection and brains were analyzed for cell proliferation (Ki67-labeling) or immature neurons (doublecortin-labeling). Results show that in both males and females high CORT, but not low CORT, reduced both cell proliferation and the density of immature neurons in the dentate gyrus. Furthermore, high CORT males had reduced density in immature neurons in both the ventral and dorsal regions while high CORT females only showed the reduced density of immature neurons in the ventral hippocampus. The high dose of CORT disrupted the estrous cycle of females. Further, the low dose of CORT significantly reduced weight gain and increased basal CORT levels in males but not females, suggesting a greater vulnerability in males with the lower dose of CORT. Thus we find subtle sex differences in the response to chronic CORT on both body weight and on neurogenesis in the dorsal dentate gyrus that may play a role in understanding different vulnerabilities to stress-related neuropsychiatric disorders between the sexes.
S Brummelte; L A M Galea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-18
Journal Detail:
Title:  Neuroscience     Volume:  168     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-90     Citation Subset:  IM    
Copyright Information:
Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Department of Psychology, University of British Columbia, 2136 West Mall, V6T 1Z4 Vancouver, BC, Canada.
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MeSH Terms
Body Weight / drug effects
Cell Count
Cell Proliferation
Cell Survival / drug effects
Corticosterone / blood,  pharmacology*
Dentate Gyrus / anatomy & histology,  cytology,  drug effects*
Estrus / drug effects
Neurons / cytology,  drug effects
Organ Size / drug effects
Rats, Sprague-Dawley
Sex Factors
Reg. No./Substance:

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