Document Detail


Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin.
MedLine Citation:
PMID:  22334369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Treatment with pioglitazone before and during treatment with peginterferon alpha-2a plus ribavirin improved several indices of glycemic control in patients with chronic hepatitis C and insulin resistance, but did not improve virologic response rates compared with peginterferon alpha-2a plus ribavirin alone.
Authors:
Stephen A Harrison; Fayez M Hamzeh; Jian Han; Prashant K Pandya; Muhammed Y Sheikh; John M Vierling
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2012-06-11
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-11     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
Division of Gastroenterology and Hepatology, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA. STEPHEN.A.HARRISON@us.army.mil
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiviral Agents / administration & dosage,  adverse effects
Diabetes Mellitus, Type 2 / drug therapy,  epidemiology
Drug Therapy, Combination
Female
Follow-Up Studies
Genotype
Hepacivirus / drug effects*,  genetics
Hepatitis C, Chronic / drug therapy*,  epidemiology,  virology
Humans
Hypoglycemic Agents / administration & dosage,  adverse effects
Insulin Resistance / physiology*
Interferon-alpha / administration & dosage*,  adverse effects
Liver Cirrhosis / epidemiology,  virology
Male
Middle Aged
Polyethylene Glycols / administration & dosage*,  adverse effects
Recombinant Proteins / administration & dosage,  adverse effects
Ribavirin / administration & dosage*,  adverse effects
Risk Factors
Thiazolidinediones / administration & dosage*,  adverse effects
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Hypoglycemic Agents; 0/Interferon-alpha; 0/Polyethylene Glycols; 0/Recombinant Proteins; 0/Thiazolidinediones; 0/peginterferon alfa-2a; 36791-04-5/Ribavirin; X4OV71U42S/pioglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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