Document Detail


Chronic hepatitis E infection in lung transplant recipients.
MedLine Citation:
PMID:  23415316     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Hepatitis E virus (HEV) genotype 3 has been identified in patients with autochthonous HEV infections in developed countries and is currently being recognized as an emerging zoonotic pathogen. HEV infection may lead to a chronic hepatitis in immune-compromised patients.
METHODS: We studied the incidence of HEV in adult lung transplant recipients at the Medical University Vienna and the University Medical Center Groningen. These recipients presented with elevated liver test results during the post-transplant follow-up period. The time of infection was investigated using stored specimens, and the HEV genotype was determined by sequence analysis of the open reading frame (ORF)1 and ORF2 region.
RESULTS: The study included 468 adult lung transplant recipients. Ten patients (2.1%) tested positive for HEV RNA. At the time of HEV detection, all patients had elevated liver test results, with median alanine aminotransferase levels of 77 U/liter and showed a mild hepatitis. A chronic HEV infection was diagnosed in the 8 lung transplant recipients who survived longer than 6 months after transplantation. Viral genotyping revealed only genotype 3 strains. In 2 of the lung transplant recipients treated with oral ribavirin monotherapy, HEV RNA was cleared from the plasma within 2 months with simultaneous normalization of alanine aminotransferase levels.
CONCLUSIONS: Chronic HEV is an important cause of liver test abnormalities after lung transplantation; therefore, routine screening for HEV RNA is strongly recommended in lung transplant recipients. Oral ribavirin appears to be a safe and effective treatment for chronic HEV infection in lung transplant recipients.
Authors:
Annelies Riezebos-Brilman; Elisabeth Puchhammer-Stöckl; Hinke Y van der Weide; Elizabeth B Haagsma; Peter Jaksch; Isabella Bejvl; Hubert G Niesters; Erik A M Verschuuren
Related Documents :
23356456 - Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obli...
24063316 - Cxcr3 ligands are associated with the continuum of diffuse alveolar damage to chronic l...
9089236 - Successful emergency transplantation of a liver allograft from a donor maintained on ex...
23602066 - Surgical lung biopsy in transplant patients with diffuse lung disease: how much worse w...
16584646 - Establishment of submandibular gland allotransplantation model in miniature swine.
3089686 - Long-term normoglycemia in pancreatectomized dogs transplanted with frozen/thawed pancr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  32     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Departments of Medical Microbiology, Division of Clinical Virology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Risk stratification of ambulatory patients with advanced heart failure undergoing evaluation for hea...
Next Document:  Neutrophils are responsible for impaired medial smooth muscle cell recovery and exaggerated allograf...