Document Detail

Chronic hepatitis C: retreatment of relapsers. An evidence-based approach.
MedLine Citation:
PMID:  10803635     Owner:  NLM     Status:  MEDLINE    
Post-treatment relapse remains a major issue in the long-term management of chronic hepatitis C. Many studies have been conducted to identify the ideal therapy that would increase the cost-effectiveness of retreatment in the individual patient. Although the conclusions of two consensus conferences for the retreatment of relapse of chronic hepatitis C have been published recently, several important issues still remain unanswered. We reviewed the available data by an evidence-based approach and conclude the following: (1) patients should be retreated with a combination of interferon (IFN) and ribavirin for 6 months if there are no contraindications to ribavirin; (2) the excellent tolerability and the lesser expense of retreatment with IFN monotherapy makes it a low-cost option for patients who have transiently cleared HCV-RNA during the first IFN course, and a primary indication for those who are contraindications to ribavirin or are likely to experience adverse events under ribavirin; (3) relapsers retreated with monotherapy must receive a high dose of IFN; and (4) patients with cirrhosis should not be retreated with IFN alone. More data, particularly on the long-term course of patients retreated with combination therapy, are needed before setting guidelines for retreatment of relapsers.
C Cammà; A Craxì
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in gastrointestinal disease     Volume:  11     ISSN:  1049-5118     ISO Abbreviation:  Semin. Gastrointest. Dis.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9100391     Medline TA:  Semin Gastrointest Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  IM    
Istituto Metodologie Diagnostiche Avanzate, Consiglio Nazionale delle Ricerche, Palermo, Italy.
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MeSH Terms
Antiviral Agents / administration & dosage*
Drug Therapy, Combination
Evidence-Based Medicine / methods*
Hepatitis C, Chronic / diagnosis,  drug therapy*,  physiopathology
Interferons / administration & dosage*
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Antiviral Agents; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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