Document Detail

Chronic hepatitis B: problem patients (including patients with decompensated disease).
MedLine Citation:
PMID:  7602076     Owner:  NLM     Status:  MEDLINE    
Most patients with chronic hepatitis B do not respond to a 4-month course of interferon alpha (IFN-alpha) and require alternative therapy. This paper focuses on alternative treatments for patients who are resistant to conventional IFN regimens (primary nonresponders) and those in whom therapy presents a special challenge. Problem patients include healthy hepatitis B surface antigen (HBsAg) carriers and those with minimal serum aminotransferase elevations, immunosuppressed patients, and patients with end-stage liver disease. Special emphasis is given to patients with decompensated liver disease. While dramatic responses to IFN-alpha can occasionally occur in these patients, serious side-effects are common.
R P Perrillo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hepatology     Volume:  22     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  IM    
Washington University School of Medicine, St. Louis, MO, USA.
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MeSH Terms
Chronic Disease
Drug Resistance
Hepatitis B / complications,  enzymology,  therapy*
Hepatitis B Surface Antigens / blood
Immunosuppression / adverse effects
Interferon-alpha / therapeutic use*
Randomized Controlled Trials as Topic
Transaminases / blood
Treatment Outcome
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Interferon-alpha; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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