Document Detail

Chronic hemodynamic effects after radiofrequency catheter ablation of frequent monomorphic ventricular premature beats.
MedLine Citation:
PMID:  16191115     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Radiofrequency catheter ablation (RFCA) of severely symptomatic monomorphic ventricular premature beats (VPBs) is reported to be a safe and effective treatment option. However, the chronic hemodynamic effects of these VPBs have not been precisely evaluated. METHODS AND RESULTS: We sought to investigate chronic effects after decreasing the number of VPBs by RFCA. A total of 47 patients who had no underlying heart disease and frequent monomorphic VPBs, consisting of more than 10,000 beats per day (24,194 +/- 12,516 beats per day), were enrolled. Patients were treated with RFCA and followed up over 6 months as outpatients. Echocardiography and serum B-type natriuretic peptide (BNP) level were repeatedly checked before and after RFCA. In 38 patients, whose VPBs were dramatically decreased to less than 1,000 beats per day by successful RFCA, left ventricular (LV) end-diastolic dimension (LVEDd) and end-systolic dimension (LVESd) measured by echocardiography decreased significantly (LVEDd: 50 +/- 5 to 48 +/- 5 mm, P < 0.01; LVESd: 33 +/- 7 to 30 +/- 6 mm, P < 0.01) in association with improvement of BNP level (39.9 +/- 34.1 to 16.8 +/- 10.3 pg/mL, P = 0.0001). In nine patients, whose VPBs were treated unsuccessfully by RFCA or that recurred, LV dimensions and BNP level did not change during the follow-up period. CONCLUSION: Significant improvement in LV dimensions and serum BNP level appeared to indicate that RFCA of VPBs ameliorated occult cardiac dysfunction induced by frequent VPBs.
Yukio Sekiguchi; Kazutaka Aonuma; Yasuteru Yamauchi; Tohru Obayashi; Akihiro Niwa; Hitoshi Hachiya; Atsushi Takahashi; Junichi Nitta; Yoshito Iesaka; Mitsuaki Isobe
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  16     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2006-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-63     Citation Subset:  IM    
Cardiovascular Division, Musashino Red Cross Hospital, Tokyo, Japan.
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MeSH Terms
Biological Markers / blood
Catheter Ablation*
Electrophysiologic Techniques, Cardiac
Follow-Up Studies
Heart Ventricles / physiopathology,  ultrasonography
Middle Aged
Natriuretic Peptide, Brain / metabolism
Stroke Volume
Time Factors
Treatment Outcome
Ventricular Premature Complexes / blood,  physiopathology*,  surgery*
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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