| Chronic heat stress up-regulates leptin and adiponectin secretion and expression and improves leptin, adiponectin and insulin sensitivity in mice. | |
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MedLine Citation:
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PMID: 22279186 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Heat stress induces adaptive responses that are responsible for alterations of carbohydrate and lipid metabolism. This study aimed to evaluate the effects of chronic heat treatment on the expression and secretion of leptin and adiponectin, important regulators of energy homeostasis, food intake and insulin action. C57BL/6 mice were subdivided into three groups (24 mice each). The first group was kept under control conditions (C: 22±2 °C). The second group was exposed to heat stress (HS: 35±1 °C). The third group was kept under C conditions and was food-restricted (FR). The HS group had higher rectal temperature compared with C and FR and lower food intake compared with C. Hspa1 gene expression in adipose tissue, muscle and liver was higher under HS than FR and C conditions. Heat treatment resulted in decreased blood glucose and non-esterified fatty acids; increased leptin, adiponectin and insulin secretion; and greater glucose disposal. Leptin, adiponectin, leptin and adiponectin receptors, insulin receptor substrate-1 and glucose transporter mRNAs were up-regulated in HS mice. This study provides evidence that heat stress improves leptin and adiponectin signalling in adipose tissue, muscle and liver. Heat stress was responsible for improving insulin sensitivity and glucose uptake in peripheral tissues, probably mediated by adipokines. Changes in the adipokine levels and sensitivity to them may be considered an adaptive response to heat. |
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Authors:
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Patrizia Morera; Loredana Basirico'; Kenji Hosoda; Umberto Bernabucci |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Journal of molecular endocrinology Volume: - ISSN: 1479-6813 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902617 Medline TA: J Mol Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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P Morera, viterbo, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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