Document Detail

Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise.
MedLine Citation:
PMID:  1555629     Owner:  NLM     Status:  MEDLINE    
Nineteen men (mean age 44 years) with essential hypertension, WHO stage I, were studied invasively at rest and during exercise. Blood pressure was recorded intra-arterially (brachial artery), cardiac output by dye dilution method and heart rate by electrocardiography. After initial pre-drug recordings, the patients received 25 mg carvedilol orally and central haemodynamics at rest and during exercise were recorded 1 and 2 h after tablet intake to evaluate the immediate effects of carvedilol. The results indicated a combined beta-blocking and vasodilating effect. After 6-9 months of treatment, supine haemodynamics were recorded 12-24 h after the last dose and then 1 and 2 h after an additional 25 mg dose. During chronic treatment (2 h after last dose at rest supine) mean arterial pressure was reduced by 17% (P less than 0.001) and total peripheral resistance index by 6% (NS) while heart rate and cardiac index were reduced by 12%. Exercise haemodynamics demonstrated a fall in blood pressure of 17% (P less than 0.001). Exercise stroke index increased by 5% (NS), partly compensating for the reduction in heart rate of 17%. Total peripheral resistance index was reduced by 5% (NS). It is concluded that carvedilol is an effective anti-hypertensive agent in a large proportion of patients with essential hypertension. The haemodynamic mode of action reflects an alpha 1-blocking activity, particularly in situations with low sympathetic tone. During exercise the beta 1-blocking activity (demonstrated by the reduction in heart rate) is more prominent.
P Lund-Johansen; P Omvik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-01     Completed Date:  1992-05-01     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Norway.
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MeSH Terms
Administration, Oral
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects
Carbazoles / administration & dosage*
Exercise Test / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*
Long-Term Care
Middle Aged
Propanolamines / administration & dosage*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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