Document Detail

Chronic granulomatous disease presenting with hypogammaglobulinemia.
MedLine Citation:
PMID:  21721378     Owner:  NLM     Status:  MEDLINE    
Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder caused by inherited defects in the nicotinamide adenine dinucleotide phosphate oxidase complex. The neutrophils of patient with CGD can ingest bacteria normally, but the oxidative processes that lead to superoxide anion formation, hydrogen peroxide production, nonoxidative pathway activation, and bacterial killing are impaired. Serious infections result from microorganisms that produce catalase. Immunoglobulin levels of patients with CGD are usually normal or elevated. We describe a patient with CGD associated with hypogammaglobulinemia, an unusual co-occurrence.
D Hanoglu; T T Ozgür; D Ayvaz; M Y Köker; O Sanal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  21     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-08-04     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  310-2     Citation Subset:  IM    
Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Agammaglobulinemia / etiology*,  therapy
Anti-Bacterial Agents / therapeutic use
Antifungal Agents / therapeutic use
Bacterial Infections / drug therapy,  etiology
Candidiasis, Vulvovaginal / drug therapy,  etiology
Common Variable Immunodeficiency / complications,  diagnosis
Disease Susceptibility
Granulomatous Disease, Chronic / blood,  complications,  diagnosis*,  immunology
Immunocompromised Host
Immunoglobulins, Intravenous / therapeutic use
Lymphocyte Count
Lymphocyte Subsets / pathology
Puberty, Delayed / etiology
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Immunoglobulins, Intravenous

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