Document Detail


Chronic granulomatous disease assessed by single-cell granulocyte oxidative burst activity.
MedLine Citation:
PMID:  7719159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we report on a case of chronic granulomatous disease (CGD) in a 3-year-old boy who suffered from severe repeated bacterial infections including multiple liver abscesses. The case is of interest because (1) the disease is very rare (it is the first case of CGD diagnosed at the Clinic for Pediatric Medicine, University of Innsbruck), (2) the diagnosis, based on clinical parameters and the nitrobluetetrazolium test was completed and validated by single-cell measurements of respiratory-burst activity of the patient's granulocytes in a fluorescence-activated cell sorter (FACS), and (3) the applied FACS method, adapted in our laboratory, presents one of the most sensitive and reliable methods to evaluate this aspect of disturbed granulocyte function.
Authors:
H Wolf; M Frühwirth; C Ruedl; H P Oswald; H Fischer; G Böck; G Wick
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  106     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-22     Completed Date:  1995-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  425-7     Citation Subset:  IM    
Affiliation:
Institute for General and Experimental Pathology, School of Medicine, University of Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Cell Separation
Child, Preschool
Flow Cytometry
Granulocytes / cytology*
Granulomatous Disease, Chronic / diagnosis*
Humans
Male
Neutrophils
Respiratory Burst / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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