Document Detail

Chronic granulocytic leukemia: reassessment of morphologic and cytogenetic characteristics in Ph1-positive and Ph1-negative cases.
MedLine Citation:
PMID:  1995326     Owner:  NLM     Status:  MEDLINE    
33 cases of chronic granulocytic leukemia (CGL) were reassessed to determine if, by strict morphologic criteria. Philadelphia chromosome (Ph1)-negative CGL exists as a diagnostic entity and if Ph1-positive CGL could be distinguished from Ph1-negative CGL. Cases were reassessed using published criteria and, of 11 Ph1-negative cases, only 4 could be reclassified as myelodysplastic syndromes or undifferentiated chronic myeloproliferative disorder. Of the morphologic parameters evaluated, peripheral blood basophilia and bicytopenia proved to be good discriminators between Ph1-positive and Ph1-negative cases. As a group, Ph1-negative cases were more heterogeneous and tended to have lower hemoglobin, WBC, platelet count and absolute eosinophilia. Chromosomal abnormalities other than Ph1 were seen only in the Ph1-positive cases. Based on these findings, we conclude that Ph1-negative CGL constitutes a heterogeneous group, a subgroup of which is morphologically identical with the Ph1-positive CGL. The parameters that best discriminate between Ph1-positive and Ph1-negative cases are peripheral blood absolute basophilia and bicytopenia.
D Crisan; J C Mattson; A al-Saadi
Related Documents :
15935796 - Review of the literature on benzene exposure and leukemia subtypes.
25123846 - A systematic review of causes of sudden and severe headache (thunderclap headache): sho...
12377426 - Traffic density and the risk of childhood leukemia in a los angeles case-control study.
3946006 - An anti-i biphasic hemolysin in chronic paroxysmal cold hemoglobinuria.
23393356 - Primary vesical clear cell adenocarcinoma arising in endometriosis: a rare case of mull...
8346766 - Rupture of the pectoralis major muscle in a collegiate football player. use of magnetic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  46     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-28     Completed Date:  1991-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Department of Clinical Pathology, William Beaumont Hospital, Royal Oak, MI 48072.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Basophils / pathology
Bone Marrow / pathology
Diagnosis, Differential
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis,  genetics*,  pathology
Middle Aged
Myelodysplastic Syndromes / diagnosis
Myeloproliferative Disorders / diagnosis
Philadelphia Chromosome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influences of antiplatelet autoantibodies on platelet function in immune thrombocytopenic purpura.
Next Document:  Retinoic acid inhibits sodium butyrate-induced monocytic differentiation of HL60 cells while synergi...