Document Detail


Chronic granulocytic leukemia: reassessment of morphologic and cytogenetic characteristics in Ph1-positive and Ph1-negative cases.
MedLine Citation:
PMID:  1995326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
33 cases of chronic granulocytic leukemia (CGL) were reassessed to determine if, by strict morphologic criteria. Philadelphia chromosome (Ph1)-negative CGL exists as a diagnostic entity and if Ph1-positive CGL could be distinguished from Ph1-negative CGL. Cases were reassessed using published criteria and, of 11 Ph1-negative cases, only 4 could be reclassified as myelodysplastic syndromes or undifferentiated chronic myeloproliferative disorder. Of the morphologic parameters evaluated, peripheral blood basophilia and bicytopenia proved to be good discriminators between Ph1-positive and Ph1-negative cases. As a group, Ph1-negative cases were more heterogeneous and tended to have lower hemoglobin, WBC, platelet count and absolute eosinophilia. Chromosomal abnormalities other than Ph1 were seen only in the Ph1-positive cases. Based on these findings, we conclude that Ph1-negative CGL constitutes a heterogeneous group, a subgroup of which is morphologically identical with the Ph1-positive CGL. The parameters that best discriminate between Ph1-positive and Ph1-negative cases are peripheral blood absolute basophilia and bicytopenia.
Authors:
D Crisan; J C Mattson; A al-Saadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  46     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-28     Completed Date:  1991-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Affiliation:
Department of Clinical Pathology, William Beaumont Hospital, Royal Oak, MI 48072.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Basophils / pathology
Bone Marrow / pathology
Child
Diagnosis, Differential
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis,  genetics*,  pathology
Leukopenia
Male
Middle Aged
Myelodysplastic Syndromes / diagnosis
Myeloproliferative Disorders / diagnosis
Philadelphia Chromosome*
Thrombocytopenia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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