| Chronic granulocytic leukemia: reassessment of morphologic and cytogenetic characteristics in Ph1-positive and Ph1-negative cases. | |
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MedLine Citation:
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PMID: 1995326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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33 cases of chronic granulocytic leukemia (CGL) were reassessed to determine if, by strict morphologic criteria. Philadelphia chromosome (Ph1)-negative CGL exists as a diagnostic entity and if Ph1-positive CGL could be distinguished from Ph1-negative CGL. Cases were reassessed using published criteria and, of 11 Ph1-negative cases, only 4 could be reclassified as myelodysplastic syndromes or undifferentiated chronic myeloproliferative disorder. Of the morphologic parameters evaluated, peripheral blood basophilia and bicytopenia proved to be good discriminators between Ph1-positive and Ph1-negative cases. As a group, Ph1-negative cases were more heterogeneous and tended to have lower hemoglobin, WBC, platelet count and absolute eosinophilia. Chromosomal abnormalities other than Ph1 were seen only in the Ph1-positive cases. Based on these findings, we conclude that Ph1-negative CGL constitutes a heterogeneous group, a subgroup of which is morphologically identical with the Ph1-positive CGL. The parameters that best discriminate between Ph1-positive and Ph1-negative cases are peripheral blood absolute basophilia and bicytopenia. |
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Authors:
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D Crisan; J C Mattson; A al-Saadi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of haematology Volume: 46 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-28 Completed Date: 1991-03-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Affiliation:
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Department of Clinical Pathology, William Beaumont Hospital, Royal Oak, MI 48072. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Basophils / pathology Bone Marrow / pathology Child Diagnosis, Differential Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis, genetics*, pathology Leukopenia Male Middle Aged Myelodysplastic Syndromes / diagnosis Myeloproliferative Disorders / diagnosis Philadelphia Chromosome* Thrombocytopenia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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