Document Detail

Chronic granulocytic leukemia after renal transplantation.
MedLine Citation:
PMID:  6354125     Owner:  NLM     Status:  MEDLINE    
Chronic granulocytic leukemia (CGL) developed in a 31-year-old man after he underwent a third renal transplant. The leukemia was initially controlled with azathioprine sodium and prednisone therapy, but eventually it entered blast cell crisis. This was controlled with an adult acute lymphocytic leukemia protocol with an excellent response. Despite discontinuing treatment with azathioprine and with the use of busulfan to control the peripheral WBC count, the patient maintained stable renal function for one year following treatment of the blast cell crisis and subsequently died of sepsis. We suggest that CGL after renal transplantation is similar to that observed in the general population and can be treated with the usual chemotherapeutic agents for the disorder without sacrificing renal function.
K A Kirchner; J C Files; R Didlake; S Raju; R P Krueger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  143     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1984-7     Citation Subset:  AIM; IM    
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MeSH Terms
Allopurinol / therapeutic use
Azathioprine / therapeutic use
Hydroxyurea / therapeutic use
Kidney Transplantation*
Leukemia, Myeloid / drug therapy,  etiology*
Melphalan / therapeutic use
Postoperative Complications
Prednisone / therapeutic use
Reg. No./Substance:
127-07-1/Hydroxyurea; 148-82-3/Melphalan; 315-30-0/Allopurinol; 446-86-6/Azathioprine; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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