Document Detail


Chronic fetal and maternal instrumentation in pregnant sheep: effect on gestation length and birthweight.
MedLine Citation:
PMID:  20047731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective was to compare gestation length in chronically instrumented (laboratory) pregnant sheep (n = 131) and in the breeding flock (n = 476) that provided the experimental sheep. In the breeding flock, gestation length was normally distributed and varied between 141 and 151 days (mean = 147 +/- 0.1 days). In the laboratory sheep, gestation length varied between 128 and 151 days (mean = 142 +/- 1 day), and was bimodal, with 35.9% delivering preterm (<141 days). To examine potential factors that contributed to the preterm birth, a severity score was used, which comprised surgery characteristics, number of experiments and maternal or fetal complications. There was a significant inverse linear relationship (P < 0.001) between the total severity score and gestation length. The median values for the surgical (15 v. 12), overall complication (6 v. 2), maternal complication (2 v. 0) and fetal complication (2 v. 2) components were significantly greater in the preterm compared with the term groups. There was no relationship between fetal number and gestation length in either group. It is concluded that in chronic pregnant sheep preparations, there is a significant incidence of preterm birth and that this is associated with the severity of the surgical intervention and with several maternal and fetal complications.
Authors:
Natalee W Bessette; Dan W Rurak
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  22     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  459-67     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Domestic
Animals, Laboratory
Animals, Newborn
Birth Weight
Female
Fetal Blood / metabolism
Gestational Age
Pregnancy
Pregnancy Complications / veterinary
Pregnancy, Animal / physiology*
Premature Birth / etiology,  veterinary
Sheep / embryology*
Stress, Physiological
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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