Document Detail

Chronic fetal hypoxia increases activin A concentrations in the late-pregnant sheep.
MedLine Citation:
PMID:  16398778     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether activin A concentrations are altered in chronic fetal hypoxemia and intrauterine fetal growth restriction (IUGR). DESIGN: In vivo animal experimental model. SETTING: Department of Physiology, Monash University. POPULATION: Chronically catherised fetal sheep in late pregnancy. METHODS: Chronic fetal hypoxia and IUGR were experimentally induced by single umbilical artery ligation (SUAL) in catheterised fetal sheep. Maternal and fetal blood samples and amniotic fluid (AF) samples were collected during surgery and thereafter on alternate days, until the time of delivery for analyte measurement. Fetal blood gas parameters were measured daily. MAIN OUTCOME MEASURES: Plasma and AF was used to analyse activin A, prostaglandin E2 (PGE2) and cortisol and fetal blood gas analysis was undertaken in whole blood. RESULTS: SUAL produced asymmetric IUGR and non-acidaemic chronic fetal hypoxia and resulted in preterm labour (129 [3] days). AF activin A concentrations were 10-fold higher in the SUAL group than in controls whereas levels in the fetal and maternal circulations were similar between groups. CONCLUSIONS: SUAL-induced IUGR and fetal hypoxaemia increases AF activin A. This may be an important adaptive or protective response to IUGR.
V G Supramaniam; G Jenkin; J Loose; E M Wallace; S L Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  113     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-9     Citation Subset:  AIM; IM    
Department of Physiology, Monash University, Clayton, Victoria, Australia.
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MeSH Terms
Activins / blood*
Analysis of Variance
Chronic Disease
Dinoprostone / metabolism
Enzyme-Linked Immunosorbent Assay
Fetal Blood / chemistry
Fetal Growth Retardation / metabolism
Fetal Hypoxia / blood*
Gestational Age
Hydrocortisone / metabolism
Inhibin-beta Subunits / blood*
Umbilical Arteries
Reg. No./Substance:
0/activin A; 104625-48-1/Activins; 363-24-6/Dinoprostone; 50-23-7/Hydrocortisone; 93443-12-0/Inhibin-beta Subunits

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