| Chronic fetal hypoxia increases activin A concentrations in the late-pregnant sheep. | |
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MedLine Citation:
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PMID: 16398778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether activin A concentrations are altered in chronic fetal hypoxemia and intrauterine fetal growth restriction (IUGR). DESIGN: In vivo animal experimental model. SETTING: Department of Physiology, Monash University. POPULATION: Chronically catherised fetal sheep in late pregnancy. METHODS: Chronic fetal hypoxia and IUGR were experimentally induced by single umbilical artery ligation (SUAL) in catheterised fetal sheep. Maternal and fetal blood samples and amniotic fluid (AF) samples were collected during surgery and thereafter on alternate days, until the time of delivery for analyte measurement. Fetal blood gas parameters were measured daily. MAIN OUTCOME MEASURES: Plasma and AF was used to analyse activin A, prostaglandin E2 (PGE2) and cortisol and fetal blood gas analysis was undertaken in whole blood. RESULTS: SUAL produced asymmetric IUGR and non-acidaemic chronic fetal hypoxia and resulted in preterm labour (129 [3] days). AF activin A concentrations were 10-fold higher in the SUAL group than in controls whereas levels in the fetal and maternal circulations were similar between groups. CONCLUSIONS: SUAL-induced IUGR and fetal hypoxaemia increases AF activin A. This may be an important adaptive or protective response to IUGR. |
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Authors:
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V G Supramaniam; G Jenkin; J Loose; E M Wallace; S L Miller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 113 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-09 Completed Date: 2006-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 102-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, Monash University, Clayton, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activins
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blood* Analysis of Variance Animals Chronic Disease Dinoprostone / metabolism Enzyme-Linked Immunosorbent Assay Female Fetal Blood / chemistry Fetal Growth Retardation / metabolism Fetal Hypoxia / blood* Gestational Age Hydrocortisone / metabolism Inhibin-beta Subunits / blood* Ligation Pregnancy Sheep Umbilical Arteries |
| Chemical | |
Reg. No./Substance:
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0/activin A; 104625-48-1/Activins; 363-24-6/Dinoprostone; 50-23-7/Hydrocortisone; 93443-12-0/Inhibin-beta Subunits |
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