Document Detail

Chronic fatigue syndrome: oxidative stress and dietary modifications.
MedLine Citation:
PMID:  11703165     Owner:  NLM     Status:  MEDLINE    
Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear; however, a number of recent studies have shown oxidative stress may be involved in its pathogenesis. The role of oxidative stress in CFS is an important area for current and future research as it suggests the use of antioxidants in the management of CFS. Specifically, the dietary supplements glutathione, N-acetylcysteine, alpha-lipoic acid, oligomeric proanthocyanidins, Ginkgo biloba, and Vaccinium myrtillus (bilberry) may be beneficial. In addition, research on food intolerance is discussed, since food intolerance may be involved in CFS symptom presentation and in oxidation via cytokine induction. Finally, recent evidence suggests celiac disease can present with neurological symptoms in the absence of gastrointestinal symptoms; therefore, celiac disease should be included in the differential diagnosis of CFS.
A C Logan; C Wong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alternative medicine review : a journal of clinical therapeutic     Volume:  6     ISSN:  1089-5159     ISO Abbreviation:  Altern Med Rev     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9705340     Medline TA:  Altern Med Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  450-9     Citation Subset:  K    
CFS/FM Integrative Care Centre, Toronto, ON, Canada.
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MeSH Terms
Antioxidants / therapeutic use*
Celiac Disease / diagnosis
Complementary Therapies
Diagnosis, Differential
Fatigue Syndrome, Chronic / etiology*,  metabolism,  therapy*
Food Hypersensitivity / complications
Oxidative Stress / physiology*
Reg. No./Substance:

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