Document Detail

Chronic fatigue syndrome: a literature review from a physiatric perspective.
MedLine Citation:
PMID:  9558019     Owner:  NLM     Status:  MEDLINE    
To examine the literature on chronic fatigue syndrome (CFS), especially as it relates to cognitive deficits and exercise, more than 200 articles related to CFS were selected from computer-based research as well as pertinent articles noted in the references of individual articles. All were relevant articles on CFS, although articles in a foreign language were excluded. CFS is a controversial diagnosis of exclusion, but certain subgroups do appear to exist. It may represent multiple diseases or multiple stages of the same disease. Although cognitive deficits are commonly reported, the measured impairments are relatively subtle and are in the area of complex information processing speed, or efficiency. Magnetic resonance imaging, single-photon emission computer tomography, and neuroendocrine studies present preliminary evidence suggestive of the cerebral involvement primarily in the white matter. The weakness and fatigue may be the result of alterations in the central nervous system, not in the peripheral muscles. However, it is hard to separate the documented weakness and endurance deficits from deconditioning. Autonomic symptoms such as orthostatic intolerance and a predisposition to neurally mediated syncope may be explained by cardiovascular deconditioning, a postviral idiopathic autonomic neuropathy, or both. The review points out the need for more carefully designed studies of CFS that focus on the relationship between neuropathology, psychopathology and neuropsychologic functioning. The role of exercise as a stimulus for exacerbation or in treatment needs to be further studied using clear diagnostic criteria as well as control groups that carefully match the activity level.
S S Jain; J A DeLisa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  77     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-04-30     Completed Date:  1998-04-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  160-7     Citation Subset:  AIM; IM    
Department of Physical Medicine and Rehabilitation, UMDNJ-New Jersey Medical School, Newark, USA.
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MeSH Terms
Activities of Daily Living
Cognition Disorders / etiology
Diagnosis, Differential
Exercise Therapy
Fatigue Syndrome, Chronic* / diagnosis,  etiology,  rehabilitation
Risk Factors
Self-Help Groups

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