| Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. | |
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MedLine Citation:
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PMID: 12699726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic fatigue syndrome (CFS) is complex illness with unknown aetiology. Recent research shows that patients with CFS have marked alterations in microbial flora, including lowered levels of bifidobacteria and small intestinal bacterial overgrowth (SIBO). Research also indicates that CFS patients are under increased oxidative stress, have a type 2 helper cell dominate cytokine profile, frequently report allergies, have altered essential fatty acid (EFA) status and may have malabsorption of certain micronutrients. Lactic acid bacteria (LAB) have the potential to influence the immune system in CFS patients by supporting T helper cell 1 driven cellular immunity and may decrease allergies. In addition LAB are strong antioxidants, may improve EFA status, can enhance absorption of micronutrients by protecting the intestinal epithelial barrier, and have been used to treat SIBO. It is our contention that LAB may have a therapeutic role in the treatment of CFS. |
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Authors:
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Alan C Logan; A Venket Rao; Dinaz Irani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 60 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-04-17 Completed Date: 2004-01-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 915-23 Citation Subset: IM |
Affiliation:
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CFS-FM Integrative Care Centre, Toronto, Canada. aclnd@cfs-fm.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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metabolism* Fatigue Syndrome, Chronic / immunology, microbiology*, therapy* Humans Immunotherapy / methods* Intestinal Mucosa / microbiology* Lactobacillus* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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