| Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function. | |
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MedLine Citation:
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PMID: 19534728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular and autonomic dysfunction have been suggested to underlie the symptoms accompanying CFS (chronic fatigue syndrome). In the present issue of Clinical Science, Hurwitz and co-workers have investigated whether deficits were present in cardiac output and blood volume in a cohort of patients with CFS and if these were linked to illness severity and sedentary lifestyle. The results clearly demonstrate reduced cardiac stroke volume and cardiac output in more severely afflicted patients with CFS, which is primarily attributable to a measurable reduction in blood volume. Similar findings are observed in microgravity and bed rest deconditioning, in forms of orthostatic intolerance and, to a lesser extent, in sedentary people. The circulatory consequences of reduced cardiac output may help to account for many of the findings of the syndrome. |
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Authors:
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Julian M Stewart |
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Publication Detail:
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Type: Comment; Journal Article Date: 2009-10-19 |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 118 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2009-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 121-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Physiology, New York Medical College, Hawthorne, NY 10532, USA. stewart@nymc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Volume
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physiology* Cardiac Output / physiology Cardiovascular Deconditioning / physiology* Fatigue Syndrome, Chronic / physiopathology* Humans |
| Comments/Corrections | |
Comment On:
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Clin Sci (Lond). 2010 Jan;118(2):125-35
[PMID:
19469714
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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