Document Detail

Chronic exposure to mercuric chloride during gestation affects sensorimotor development and later behaviour in rats.
MedLine Citation:
PMID:  22705860     Owner:  NLM     Status:  Publisher    
The current study was performed to assess the effects of inorganic mercury (mercuric chloride-HgCl(2)) on the development of offsprings from intoxicated-mother during pregnancy. In this respect, pregnant rats were chronically treated with HgCl2 at 50ppm (Hg 50) and 100ppm (Hg 100) in drinking water. After parturition, maternal behaviour was recorded during 30min at 1st to 6th postnatal day (Pnd). The development of their offspring was studied during the first 17 days after birth. Sensorimotor development of pups was measured by different tests: rooting reflex, vibrissae placing response, righting reflex, negative geotaxis, suspension test and rotating grid. Two month after birth, the anxiety of offspring was tested using the elevated plus maze test. Our results indicate that mercury treatment significantly reduced the nursing and increased the time out the nest or drinking and eating. We also showed that prenatal exposure to HgCl(2) decreased weight gain. Importantly, the rooting reflex, the development of the vibrissae placing response, the righting reflex, the grip strength and the negative geotaxis behaviour were delayed in the offspring of dams treated with Hg 50, the delay being more severe with Hg 100. We also found a decrease in anxiety in adulthood. Cross-fostering test support the direct toxic effects of mercury.
Latifa Chehimi; Vincent Roy; Mustapha Jeljeli; Mohsen Sakly
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, 7021 Jarzouna, Tunisie.
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