| Chronic exposure to anticholinergic medications adversely affects the course of Alzheimer disease. | |
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MedLine Citation:
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PMID: 12837675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Authors examined the effect of chronic exposure to anticholinergics in a cohort of Alzheimer disease (AD) patients. METHODS: All patients were examined annually with standard neuropsychologic tests and received the cholinesterase inhibitor donepezil hydrochloride at a dose of 10 mg/day. The study population (N=69) was divided into two groups: those receiving one or more concomitant medications with significant anticholinergic properties (N=16) and those receiving no concomitant medications with anticholinergic properties (N=53). RESULTS: At 2 years, MMSE scores were significantly worse for patients receiving anticholinergic medications than for those not on anticholinergics. CONCLUSION: Although very preliminary, these data suggest that concomitant therapy with anticholinergics may be associated with significant deleterious effects on acetylcholinesterase therapy, or, more speculatively, that chronic exposure to anticholinergics may have adverse effects on the clinical course of AD. |
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Authors:
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Ching-ju Lu; Larry E Tune |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry Volume: 11 ISSN: 1064-7481 ISO Abbreviation: Am J Geriatr Psychiatry Publication Date: 2003 Jul-Aug |
Date Detail:
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Created Date: 2003-07-02 Completed Date: 2003-11-12 Revised Date: 2007-07-16 |
Medline Journal Info:
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Nlm Unique ID: 9309609 Medline TA: Am J Geriatr Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 458-61 Citation Subset: IM |
Affiliation:
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Department of Psychiatry at Wesley Woods Geriatric Teaching and Research Hospital, Emory University School of Medicine, Atlanta, Georgia 30329-5102, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / drug therapy*, psychology Cholinesterase Inhibitors / administration & dosage, adverse effects, therapeutic use* Drug Administration Schedule Female Humans Indans / administration & dosage, adverse effects, therapeutic use* Male Piperidines / administration & dosage, adverse effects, therapeutic use* Psychomotor Agitation / epidemiology, etiology Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 120011-70-3/donepezil |
| Comments/Corrections | |
Comment In:
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Am J Geriatr Psychiatry. 2007 Apr;15(4):357-9
[PMID:
17384320
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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