| Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs. | |
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MedLine Citation:
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PMID: 10658009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that exercise training would lead to enhanced endothelium-dependent vasodilation in porcine pulmonary arteries. Pulmonary artery rings (2- to 3-mm OD) were obtained from female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder). Exercise training was performed for 16 wk, and vasomotor responses were studied by using standard isometric techniques. Contractile responses to 80 mM KCl, isosmotic KCl (10-100 mM), and norepinephrine (10(-8) to 10(-4) M) did not differ between sedentary (Sed) and exercise-trained (Ex) pigs. Relaxation was assessed to endothelium-dependent and endothelium-independent vasodilators after norepinephrine contraction. Pulmonary arteries of Ex pigs exhibited greater maximal relaxation to ACh (61.9 +/- 3.5%) than did those of Sed pigs (52.3 +/- 3.9%; P < 0.05). Endothelium-independent relaxation to sodium nitroprusside did not differ. Inhibition of nitric oxide synthase significantly decreased acetylcholine-induced relaxation, with greater inhibition in arteries from Ex pigs (P < 0.05). Inhibition of cyclooxygenase enhanced relaxation to acetylcholine in arteries from Sed pigs. We conclude that exercise training enhances endothelium-dependent (ACh-mediated) vasorelaxation in pulmonary arteries by mechanisms of increased reliance on nitric oxide and reduced production of a prostanoid constrictor. |
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Authors:
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L R Johnson; J L Parker; M H Laughlin |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 88 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-03 Completed Date: 2000-03-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 443-51 Citation Subset: IM |
Affiliation:
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Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA. JohnsonLR@missouri.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Animals Bradykinin / pharmacology Dose-Response Relationship, Drug Endothelium, Vascular / drug effects, physiology Enzyme Inhibitors / pharmacology Female Indomethacin / pharmacology NG-Nitroarginine Methyl Ester / pharmacology Nitroprusside / pharmacology Norepinephrine / pharmacology Physical Conditioning, Animal / physiology* Potassium Chloride / pharmacology Pulmonary Artery / drug effects*, physiology Swine Swine, Miniature Vasoconstriction / drug effects Vasodilation / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-03856/HL/NHLBI NIH HHS; HL-36088/HL/NHLBI NIH HHS; HL-52490/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 15078-28-1/Nitroprusside; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 53-86-1/Indomethacin; 58-82-2/Bradykinin; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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