| Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection. | |
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MedLine Citation:
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PMID: 19811098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is assumed that moderate exercise may improve resistance to infection and reduce inflammation, but there are limited data to support this assumption in an infection model. METHODS: BALB/cJ mice were assigned to the following groups: no exercise (NON-EX), 1 session of acute exercise (A-EX), or chronic exercise for approximately 3.5 months (C-EX). Mice were infected with influenza (C-EX mice infected at rest; A-EX mice infected 15 min after exercise). RESULTS: C-EX mice demonstrated the lowest severity of infection, assessed by body weight loss and food intake. There was less virus in the lungs at day 5 after infection in C-EX and A-EX mice compared with NON-EX mice (P = .02) and less virus at day 2 after infection only in C-EX mice (P = .07). Soon after infection (day 2), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1beta, and tumor necrosis factor alpha in the bronchoalveolar lavage (BAL) fluid were lower in C-EX and A-EX than in NON-EX mice. At day 5 after infection, the BAL fluid from C-EX (but not A-EX) mice had less IL-6, interleukin 12p40, granulocyte colony-stimulating factor, keratinococyte-derived chemokine, and MCP-1 than that from NON-EX mice. A trend toward reduced immunopathologic response was found in C-EX mice. CONCLUSIONS: Chronic exercise resulted in reduced symptoms, virus load, and levels of inflammatory cytokine and chemokines. Acute exercise also showed some benefit, which was limited to the early phase of infection. |
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Authors:
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Young-Je Sim; Shan Yu; Kyoung-Jin Yoon; Kyoungjin J Yoon; Christie M Loiacono; Marian L Kohut |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 200 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-12 Completed Date: 2009-11-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1434-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Immunobiology, College of Human Sciences, Iowa State University, Ames, Iowa 50011-1160, USA. mkohut@iastate.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / immunology Chemokines / analysis Disease Models, Animal Exercise Therapy / methods* Humans Influenza A virus* Male Mice Mice, Inbred BALB C Orthomyxoviridae Infections / immunology*, physiopathology, prevention & control* Physical Fitness Severity of Illness Index Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI059455-01/AI/NIAID NIH HHS; R01 AI059455-02/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokines |
| Comments/Corrections | |
Erratum In:
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J Infect Dis. 2009 Dec 15;200(12):1949 Note: Yoon, Kyoungjin J [corrected to Yoon, Kyoung-Jin] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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