| Chronic exercise decreases cytokine production in healthy rat skeletal muscle. | |
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MedLine Citation:
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PMID: 19681095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal muscle is the source of pro- and anti-inflammatory cytokines, and recently, it has been recognized as an important source of interleukin-6 (IL-6). Acute physical exercise is known to induce a pro-inflammatory cytokine profile in the plasma. However, the effect of chronic physical exercise in the production of pro- and anti-inflammatory cytokines by the skeletal muscle has never been examined. We assessed IL-6, TNF-alpha, IL-1beta and IL-10 levels in the skeletal muscle of rats submitted to endurance training. Animals were randomly assigned to either a sedentary group (S, n = 7) or an endurance exercise trained group (T, n = 8). Trained rats ran on a treadmill for 5 days week(-1) for 8 weeks (60% VO(2max)). Detection of IL-6, TNF-alpha, IL-1beta and IL-10 protein expression was carried out by ELISA. We found decreased expression of IL-1beta, IL-6, TNF-alpha and IL-10 (28%, 27%, 32% and 37%, respectively, p < 0.05) in the extensor digital longus (EDL) from T, when compared with S. In the soleus, IL-1beta, TNF-alpha and IL-10 protein levels were similarly decreased (34%, 42% and 50%, respectively, p < 0.05) in T in relation to S, while IL-6 expression was not affected by the training protocol. In conclusion, exercise training induced decreased cytokine protein expression in the skeletal muscle. These data show that in healthy rats, 8-week moderate-intensity aerobic training down regulates skeletal muscle production of cytokines involved in the onset, maintenance and regulation of inflammation, and that the response is heterogeneous according to fibre composition. |
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Authors:
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Fábio S Lira; Cristiane H Koyama; Alex S Yamashita; José C Rosa; Nelo E Zanchi; Miguel L Batista; Marília C Seelaender |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 27 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-01 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 458-61 Citation Subset: IM |
Affiliation:
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Molecular Biology of the Cell Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / biosynthesis* Health* Male Muscle, Skeletal / metabolism* Physical Conditioning, Animal* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
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