Document Detail


Chronic ethanol exposure and folic acid supplementation: fetal growth and folate status in the maternal and fetal guinea pig.
MedLine Citation:
PMID:  21315145     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic ethanol exposure (CEE) can produce developmental abnormalities in the CNS of the embryo and developing fetus. Folic acid (FA) is an important nutrient during pregnancy and low folate status exacerbates ethanol-induced teratogenicity. This study tested the hypotheses that (1) CEE depletes folate stores in the mother and fetus; and (2) maternal FA supplementation maintains folate stores. CEE decreased fetal body, brain, hippocampus weights, and brain to body weight ratio but not hippocampus to body weight ratio. These effects of CEE were not mitigated by maternal FA administration. The FA regimen prevented the CEE-induced decrease of term fetal liver folate. However, it did not affect maternal liver folate or fetal RBC folate at term, and did not mitigate the nutritional deficit-induced decrease of term fetal hippocampus folate. This study suggests that maternal FA supplementation may have differential effects on folate status in the mother and the fetus.
Authors:
Amy J Hewitt; Amber L Knuff; Matthew J Jefkins; Christine P Collier; James N Reynolds; James F Brien
Related Documents :
18027075 - Tgfbeta as a potential mediator of progesterone action in the mammary gland of pregnancy.
21112135 - Factors influencing the duration of late first and second-trimester termination of preg...
21290395 - Umbilical cord insertion into the lower segment of the uterus at 11 to 13 weeks' gestat...
21492325 - Non-invasive tool for foetal sex determination in early gestational age.
7316965 - The measurement of the intrinsic alkaline bohr effect of various human haemoglobins by ...
9532995 - Increase in incidence of gastroschisis in the south west of england in 1995.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  -     ISSN:  1873-1708     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: improved in vitro ...
Next Document:  High-resolution melting curve analysis to establish CYP2C19*2 single nucleotide polymorphism: compar...