| Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster. | |
| | |
MedLine Citation:
|
PMID: 19553498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acute ethanol (EtOH) administration impairs circadian clock phase resetting, suggesting a mode for the disruptive effect of alcohol abuse on human circadian rhythms. Here, we extend this research by characterizing the chronobiological effects of chronic alcohol consumption. First, daily profiles of EtOH were measured in the suprachiasmatic nucleus (SCN) and subcutaneously using microdialysis in hamsters drinking EtOH. In both cases, EtOH peaked near lights-off and declined throughout the dark-phase to low day-time levels. Drinking bouts preceded EtOH peaks by approximately 20 min. Second, hamsters chronically drinking EtOH received a light pulse during the late dark phase [Zeitgeber time (ZT) 18.5] to induce photic phase advances. Water controls had shifts of 1.2 +/- 0.2 h, whereas those drinking 10% and 20% EtOH had much reduced shifts (0.5 +/- 0.1 and 0.3 +/- 0.1 h, respectively; P < 0.001 vs. controls). Third, incremental decreases in light intensity (270 lux to 0.5 lux) were used to explore chronic EtOH effects on photic entrainment and rhythm stability. Activity onset was unaffected by 20% EtOH at all light intensities. Conversely, the 24-h pattern of activity bouts was disrupted by EtOH under all light intensities. Finally, replacement of chronic EtOH with water was used to examine withdrawal effects. Water controls had photic phase advances of 1.1 +/- 0.3 h, while hamsters deprived of EtOH for 2-3 days showed enhanced shifts (2.1 +/- 0.3 h; P < 0.05 vs. controls). Thus, in chronically drinking hamsters, brain EtOH levels are sufficient to inhibit photic phase resetting and disrupt circadian activity. Chronic EtOH did not impair photic entrainment; however, its replacement with water potentiated photic phase resetting. |
| | |
Authors:
|
Christina L Ruby; Allison J Brager; Marc A DePaul; Rebecca A Prosser; J David Glass |
Related Documents
:
|
17084868 - Photic and non-photic effects on the daily activity pattern of mongolian gerbils. 19424498 - Diurnally entrained anticipatory behavior in archaea. 7772798 - Sensitivity of the human circadian pacemaker to moderately bright light. 3351788 - Characterization of circadian function in djungarian hamsters insensitive to short day ... 17952058 - Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singul... 6631738 - Directional tuning interactions between moving oriented and textured stimuli in complex... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-06-24 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 297 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-08-25 Completed Date: 2009-09-10 Revised Date: 2011-01-18 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R729-37 Citation Subset: IM |
Affiliation:
|
Dept. Biological Sciences, Kent State Univ., Kent, OH 44242, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcohol Drinking* Animals Behavior, Animal / drug effects* Circadian Rhythm / drug effects* Cricetinae Ethanol / pharmacokinetics, toxicity* Male Mesocricetus Microdialysis Photic Stimulation Photoperiod* Substance Withdrawal Syndrome / metabolism, physiopathology Suprachiasmatic Nucleus / drug effects*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
AA-015948/AA/NIAAA NIH HHS; R01 AA017898-02/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Olive oil-supplemented diet alleviates acute heat stress-induced mitochondrial ROS production in chi...
Next Document: Functional overload in ground squirrel plantaris muscle fails to induce myosin isoform shifts.