Document Detail


Chronic erosive gastritis--a therapeutic approach with bismuth.
MedLine Citation:
PMID:  3166538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
37 patients with epigastric pain and chronic erosive gastritis underwent an open controlled therapeutic trial with bismuthsubsalicylate (BS). Group A (21 patients) was treated with BS, liquid, 4 X 314 mg for three weeks, group B (16 patients) with BS tablets, 3 X 300 mg for two weeks. A significant reduction of symptoms (p less than 0.001) and endoscopically assessed chronic erosions (p less than 0.001) was achieved in both groups. Campylobacter pylori was detected in 89% of the patients before treatment, but was absent in 78% of the patients after treatment. The histological grading of antral mucosa showed a significant reduction (p less than 0.001) of polymorphonuclear cell (PML) infiltration after two and three weeks treatment respectively. While in group A PML cells had disappeared from gastric mucosa in all but two patients, in group B 50% of the patients had some degree of PML cell infiltration left in the antral mucosa. This study confirms the beneficial effect of BS in the treatment of C. pylori associated active chronic gastritis and reemphasizes the pathogenetic role of C. pylori in this disease.
Authors:
P Malfertheiner; A Stanescu; K Baczako; G Bode; H Ditschuneit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  142     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-24     Completed Date:  1988-10-24     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine II, University Clinic Ulm, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bismuth*
Campylobacter / drug effects*
Chronic Disease
Female
Gastritis / drug therapy*,  microbiology,  pathology
Gastroscopy
Humans
Male
Middle Aged
Organometallic Compounds / therapeutic use*
Pyloric Antrum / pathology
Salicylates / therapeutic use*
Stomach / pathology,  ultrastructure
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 0/Salicylates; 14882-18-9/bismuth subsalicylate; 7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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