Document Detail


Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease.
MedLine Citation:
PMID:  9012697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hypereosinophilic syndrome. We report a patient with a white blood cell count of 17.6 x 10(9)/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was < 3%. A diagnosis of chronic eosinophilic leukaemia was made. Chromosome analysis of a bone marrow aspirate disclosed a trisomy 15 together with loss of the Y chromosome. Moreover, FISH analysis on May-Grünwald-Giemsa-stained peripheral blood smears demonstrated trisomy 15 in the eosinophils. 3 months after initial diagnosis the patient went into blast crisis and died. The blast cells exhibited trisomy 15 and loss of the Y chromosome in a complex, aberrant karyotype. In conclusion, the case shows that chronic eosinophilic leukaemia is a monoclonal, myeloproliferative disease with eosinophils as part of the malignant clone. Clinically, chronic eosinophilic leukaemia can be separated into a chronic phase and a blast crisis.
Authors:
R Weide; H Rieder; Y Mehraein; M Wolf; U Kaiser; U Seifart; C Görg; K Havemann
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  96     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-02-19     Completed Date:  1997-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Affiliation:
Department of Haematology/Oncology, Philipps-University of Marburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Blast Crisis
Chromosomes, Human, Pair 15*
Chronic Disease
Fatal Outcome
Humans
Hypereosinophilic Syndrome / blood,  diagnosis*,  genetics
In Situ Hybridization, Fluorescence
Karyotyping
Leukocyte Count
Male
Middle Aged
Platelet Count
Trisomy*

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