Document Detail


Chronic endothelin-1 blockade preserves myocardial contractility in dilated cardiomyopathy.
MedLine Citation:
PMID:  9595466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelin-1 (ET-1) is known to have positive inotropic effects in isolated cardiac muscle strips. ET-1 levels are elevated in congestive heart failure (CHF). We investigated the effects of ET-1 on contractility and cardiac relaxation (lusitropy) of the intact healthy murine heart and myocarditic/cardiomyopathic heart by chronic oral treatment with a mixed ETA/ETB blocker SB217242. Chronic ET-1 blockade of normal hearts resulted in depression of contractility and lusitropy of the normal heart but preservation and enhancement of contractility and lusitropy in myocarditic animals, in which ET-1 cardiac content is elevated. This suggests that ET-1 is important in the basal contractility and relaxation of the normal heart but that its chronic elevation in CHF causes impairment of cardiac systolic and diastolic performance.
Authors:
A S Pandey; D J Stewart; P Cernacek; F Dawood; W H Wen; P Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  31 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-07-17     Completed Date:  1998-07-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S306-8     Citation Subset:  IM    
Affiliation:
Center for Cardiovascular Research, Toronto Hospital, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carboxylic Acids / therapeutic use*
Cardiomyopathy, Dilated / drug therapy*,  physiopathology*
Endothelin-1 / antagonists & inhibitors*,  metabolism
Hemodynamics / drug effects
Indans / therapeutic use*
Male
Mice
Mice, Inbred DBA
Myocardial Contraction / drug effects*
Myocarditis / drug therapy,  physiopathology
Myocardium / metabolism
Receptor, Endothelin A
Receptors, Endothelin / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Carboxylic Acids; 0/Endothelin-1; 0/Indans; 0/Receptor, Endothelin A; 0/Receptors, Endothelin; 0/SB 217242

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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