| Chronic endogenous hypercholecystokininemia promotes pancreatic carcinogenesis in the hamster. | |
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MedLine Citation:
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PMID: 9054623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to examine the effect of cholecystokinin on spontaneous and induced pancreatic carcinogenesis in the hamster, two sets of experiments were carried out, one involving long-term hypercholecystokininemia and one involving cancer induction during hypercholecystokininemia. The effect of hypercholecystokininemia, induced by pancreaticobiliary diversion (PBD), was studied for 8 months. Neither PBD animals nor sham-operated controls developed premalignant or malignant pancreatic lesions. However, in the PBD group the mean pancreatic weight, total protein content and DNA content were increased by 30, 29 and 27% respectively. No such increases were found in PBD animals receiving a cholecystokinin-A receptor antagonist during the last 24 days of the experiment. In the cancer induction study, the effect of PBD on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis was studied for 3 months. Putative premalignant pancreatic lesions were diagnosed in all PBD hamsters and in four of 15 sham-operated controls. Pancreatic ductular carcinoma in situ was only found in PBD animals. The [3H]thymidine labeling index of the pancreatic lesions was significantly higher in the PBD group than in the controls. No such increase was observed in PBD animals receiving a cholecystokinin-A receptor antagonist during the last 5 days of the experiment. It is concluded that chronic endogenous hypercholecystokininemia promotes early phase pancreatic carcinogenesis, but does not per se cause development of premalignant or malignant pancreatic lesions in the hamster. |
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Authors:
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M Chu; J F Rehfeld; K Borch |
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10503143 - Chronic pancreatitis and other risk factors for pancreatic cancer. 8113623 - Review of standards for reporting results of treatment of exocrine pancreatic cancer. 16556073 - The future of photodynamic therapy in oncology. |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Carcinogenesis Volume: 18 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-24 Completed Date: 1997-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 315-20 Citation Subset: IM |
Affiliation:
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Department of Surgery, University Hospital of Linköping, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens Cholecystokinin / blood* Cricetinae Duodenum / surgery* Gastrins / blood Male Mesocricetus Nitrosamines Organ Size Pancreas / drug effects, pathology Pancreatic Ducts / surgery* Pancreatic Neoplasms / chemically induced, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Gastrins; 0/Nitrosamines; 60599-38-4/nitrosobis(2-oxopropyl)amine; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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