Document Detail

Chronic effects of trichloroethylene upon S-100 protein content and lipid composition in gerbil cerebellum.
MedLine Citation:
PMID:  6474106     Owner:  NLM     Status:  MEDLINE    
Gerbil rats were exposed to trichloroethylene (TCE) vapors intermittently (8 h/d) at 510 ppm or continuously at 170 ppm for five months. The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indicated delayed astrocytic reactivity in the anterior cerebellar hemisphere and a decrease of S-100 protein in the posterior cerebellar vermis. Minor lipid changes were observed. The fatty-acid profiles of ethanolamine phosphoglycerides showed a tendency towards alterations among the 22-carbon fatty acids, with a decrease in 22:5 (N-3), similar to those shown earlier for cerebral cortex and hippocampus of the gerbil. Two monoenoic fatty acids were decreased, the 20:1 of phosphatidyl-ethanolamine and the 18:1 of the phosphatidyl-serine. This occurrence could indicate a decrease in myelin in areas where these two fatty acids were found to be enriched.
T Kyrklund; G Goracci; K G Haglid; L Rosengren; G Porcellati; P Kjellstrand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  10     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-10-12     Completed Date:  1984-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
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MeSH Terms
Cerebellum / metabolism*
Fatty Acids / metabolism
Lipid Metabolism*
Phospholipids / metabolism
Research Design
S100 Proteins / metabolism*
Time Factors
Trichloroethylene / toxicity*
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/S100 Proteins; 79-01-6/Trichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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