Document Detail


Chronic effects of serotonin inhibition in hypertensive patients: hemodynamic and humoral findings.
MedLine Citation:
PMID:  2412036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review deals with the effects of chronic antihypertensive treatment with ketanserin on a series of physiological and biochemical variables, both at rest and during stimulation (exercise or stress). In four centers, different aspects were covered, with blood pressure as the common denominator in 45 hypertensive patients. Treatment periods ran from 1 to 9 months with daily doses ranging from 80 to 160 mg. Systolic and diastolic pressures fell roughly by 10 mm Hg. Heart rate tended to be reduced. The decrease in blood pressure was accounted for mainly by a decrease in calculated total peripheral (and renal) vascular resistance. Volume parameters failed to show statistically significant changes, although plasma volume tended to expand. The profile of hemodynamics during exercise was basically unmodified. Hormonal changes were not uniform, but the main trend was a decrease in the activities of both the renin-angiotensin and the adrenergic system. Apparently the action of ketanserin is not confined to 5-HT2-serotonergic blockade.
Authors:
P W de Leeuw; W H Birkenhäger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  7 Suppl 7     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-17     Completed Date:  1985-10-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S137-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Body Weight / drug effects
Catecholamines / blood
Hemodynamics / drug effects*
Hormones / blood*
Humans
Hypertension / drug therapy*,  physiopathology
Physical Exertion
Renal Circulation / drug effects
Renin-Angiotensin System / drug effects
Serotonin Antagonists / therapeutic use*
Stress, Psychological / physiopathology
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Hormones; 0/Serotonin Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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