Document Detail

Chronic effects of an aminosteroid on microdialytically measured parameters after experimental middle cerebral artery occlusion in the rat.
MedLine Citation:
PMID:  10847651     Owner:  NLM     Status:  MEDLINE    
The effects of the neuroprotective aminosteroid U74006F (tirilazad mesylate, Freedox) were monitored microdialytically in rat cortex during three 4h periods beginning immediately, 25h and 49h after permanent middle cerebral artery occlusion. Either U74006F or vehicle only was administered 15 min, 2h, 6h, 12h and 24h after operation. The dialysate was analysed for on-line pH, ascorbic acid, uric acid, glucose and lactate. The efficacy of post-ischaemic treatment was shown by: a) lesion volume 53h after operation was significantly smaller in U74006F-treated animals; b) microdialytic findings were very similar to those found previously with pre-ischaemic drug application (reduction in release of ascorbic acid, uric acid and lactate, increased pH); c) an effect of U74006F on lactate release could still be seen on days 2 and 3; and d) increases in uric acid on days 2 and 3, possibly reflecting delayed cell death, were smaller in aminosteroid treated animals.
B Alessandri; R Basciani; H Langemann; P Lyrer; D Pluess; H Landolt; O Gratz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  7     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-07-12     Completed Date:  2000-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Department of Research, Cantonal Hospital, Basel, Switzerland.
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MeSH Terms
Ascorbic Acid / metabolism
Brain Ischemia / drug therapy*,  metabolism
Drug Evaluation, Preclinical
Free Radicals / metabolism
Glucose / metabolism
Infarction, Middle Cerebral Artery / drug therapy*,  metabolism
Lactic Acid / metabolism
Neuroprotective Agents / therapeutic use*
Pregnatrienes / therapeutic use*
Rats, Inbred SHR
Uric Acid / metabolism
Reg. No./Substance:
0/Free Radicals; 0/Neuroprotective Agents; 0/Pregnatrienes; 110101-67-2/tirilazad; 50-21-5/Lactic Acid; 50-81-7/Ascorbic Acid; 50-99-7/Glucose; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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