Document Detail

Chronic effects of alcohol on the epithelium of the small intestine using two experimental models.
MedLine Citation:
PMID:  2867635     Owner:  NLM     Status:  MEDLINE    
The effects of chronic alcohol ingestion on the rat small intestinal epithelium have been measured using two different experimental models, viz. either a solid diet plus alcohol or a liquid diet plus alcohol. All experimental animals consumed adequate quantities of food and exhibited a normal growth rate; thus the recorded effects were unlikely to be associated with malnutrition. After a period of 24 days, there were significant decreases in the jejunal villus cell population in both groups of experimental animals and corresponding increases in the crypt cell populations; no such changes were found in the ileum. Alcohol had no significant effect on the crypt cell production rate and the growth fraction at either of these two sites in the intestine, and thus the major effect of alcohol was to cause a lengthening of the cell cycle time in the jejunal crypts.
S Zucoloto; G Muccilo; N A Wright; M R Alison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. B, Cell pathology including molecular pathology     Volume:  49     ISSN:  0340-6075     ISO Abbreviation:  Virchows Arch., B, Cell Pathol.     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-28     Completed Date:  1986-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9316922     Medline TA:  Virchows Arch B Cell Pathol Incl Mol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  365-73     Citation Subset:  IM    
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MeSH Terms
Alcoholism / pathology*,  physiopathology
Body Weight / drug effects
Cell Division / drug effects
Disease Models, Animal
Energy Intake
Epithelium / pathology
Ileum / pathology
Intestinal Mucosa / pathology*
Intestine, Small / pathology*
Jejunum / pathology
Rats, Inbred Strains
Thymidine / diagnostic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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