Document Detail

Chronic effects of [D-Trp6-Pro9-NEt]luteinizing hormone-releasing factor on reproductive processes in the female rat.
MedLine Citation:
PMID:  371955     Owner:  NLM     Status:  MEDLINE    
LRF and one of its highly potent analogs, [D-Trp6-Pro9-NEt]LRF (A), were tested for their effects on pregnancy. Daily doses of A prevented implantation and/or caused resorption of implanted blastocysts in mated female rats. This effect was dose related and was most evident when given in regimens including days 5-7 or days 9-10 or pregnancy. LRF also has antigonadal effects, but at much higher doses than A. The use of corn oil vs. 0.1% gelatin-saline improved the effectiveness of low doses of A. Termination of pregnancy in A- or LRF-treated rats is most probably due to the markedly diminished progesterone secretion, which could result from the secretion of biologically inactive gonadotropins, reduced pituitary responsiveness to endogenous LRF, or down-regulation of gonadal receptors for LH.
C Rivier; J Rivier; W Vale
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  103     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-06-11     Completed Date:  1979-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2299-305     Citation Subset:  AIM; IM    
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MeSH Terms
Estrus / drug effects
Gonadotropin-Releasing Hormone / analogs & derivatives*,  pharmacology*
Luteinizing Hormone / blood
Pregnancy, Animal / drug effects*
Progesterone / blood
Reproduction / drug effects*
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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