Document Detail

Chronic effect of ketanserin in mild to moderate essential hypertension.
MedLine Citation:
PMID:  2935497     Owner:  NLM     Status:  MEDLINE    
Ketanserin, an antagonist highly selective for 5-hydroxytryptamine (serotonin) type 2 (S2) receptors, was given as monotherapy in a dose of 40 mg b.i.d. to 24 subjects with mild to moderate essential hypertension. Its effects were evaluated in a placebo-controlled double-blind crossover study. The effect on blood pressure in 18 subjects was monitored by 24-hour ambulatory intra-arterial measurements. Systolic and diastolic intra-arterial pressures were significantly lowered by ketanserin both during the day and at night, whereas heart rate was unchanged. Cuff pressure readings (triplicate measurements) with the London School of Hygiene sphygmomanometer and an automatic device (12 measurements in 1 hour) in the outpatient clinic also showed a significant effect on both supine and standing pressures. No postural hypotension was noted. Ketanserin had no effect on endogenous creatinine clearance, serum cholesterol levels, and the plasma levels of norepinephrine, renin, and aldosterone. The only side effect that was significantly more common with ketanserin than with placebo treatment was an increase in body weight. Ketanserin may have a place in the treatment of mild to moderate essential hypertension.
A J Woittiez; G J Wenting; A H van den Meiracker; H J Ritsema van Eck; A J Man in't Veld; F A Zantvoort; M A Schalekamp
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Hypertension     Volume:  8     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-06     Completed Date:  1986-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Circadian Rhythm / drug effects
Clinical Trials as Topic
Double-Blind Method
Heart Rate / drug effects
Hypertension / drug therapy*
Middle Aged
Piperidines / therapeutic use*
Random Allocation
Reg. No./Substance:
0/Piperidines; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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