Document Detail


Chronic disseminated intravascular coagulation after surgery for abdominal aortic aneurysm: clinical and haemostatic response to dalteparin.
MedLine Citation:
PMID:  11380454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 77-year-old man developed chronic disseminated intravascular coagulation (DIC) after surgical repair of a large infrarenal aortic aneurysm. Self-administered subcutaneous dalteparin therapy (5000 units o.d.) led to rapid relief of symptoms and sustained improvements in his platelet count and fibrinogen level; activation of coagulation and fibrinolysis appeared to be relatively unaffected. Long-term treatment with low-molecular-weight heparin can provide good symptomatic control of chronic DIC associated with abdominal aortic aneurysm.
Authors:
D Cummins; H Segal; B J Hunt; R Awad; A Maddox
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  113     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-30     Completed Date:  2001-07-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  658-60     Citation Subset:  IM    
Affiliation:
Royal Brompton & Harefield NHS Trust, Harefield, Middlesex, UK. david_cummins@talk21.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Anticoagulants / therapeutic use*
Antithrombins / analysis
Aortic Aneurysm, Abdominal / blood,  complications,  surgery*
Chronic Disease
Dalteparin / therapeutic use*
Disseminated Intravascular Coagulation / blood,  drug therapy*
Fibrin Fibrinogen Degradation Products / analysis
Gene Products, tat / analysis
Humans
Male
Plasminogen / analysis
Plasminogen Activator Inhibitor 1 / analysis
Platelet Count
Postoperative Complications / blood,  drug therapy*
Prothrombin / analysis
Tissue Plasminogen Activator / analysis
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Antithrombins; 0/Dalteparin; 0/Fibrin Fibrinogen Degradation Products; 0/Gene Products, tat; 0/Plasminogen Activator Inhibitor 1; 0/fibrin fragment D; 9001-26-7/Prothrombin; 9001-91-6/Plasminogen; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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