| Chronic digitalis administration alters mesenteric vascular reactivity. | |
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MedLine Citation:
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PMID: 3820409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To characterize any digitalis-induced differences in intestinal blood flow autoregulation, we studied the circulatory responses of the rat intestine in control (n = 7) and chronically digitalized (n = 7) animals. Data were generated from denervated isoperfused small intestinal preparations. Arterial pressure, venous pressure, and oxygen consumption were continuously monitored. Determinations of intestinal blood flow allowed calculation of mesenteric vascular resistance and oxygen consumption. Animals underwent stepwise reductions in arterial pressure and acute venous hypertension (10 to 15 mm Hg). There were no differences in baseline hemodynamic or metabolic parameters in control (C) or digitalized (D) animals. Blood flow and oxygen consumption were autoregulated in both C and D rats until perfusion pressure decreased below 50 mm Hg. The response to acute venous hypertension was different. In D rats, venous hypertension resulted in increased vascular resistance (millimeters of mercury per milliliter per minute per 100 gm) [0.89 +/- 0.05 to 0.97 +/- 0.07; p less than 0.05], whereas C rats demonstrated no change [0.92 +/- 0.08 to 0.95 +/- 0.09]. The decrease in oxygen consumption in D rats (-14%) was slightly but significantly greater than that observed in C rats (-9%). Digitalized rats demonstrated a heightened myogenic response to acute venous hypertension with deleterious effects on vascular resistance and oxygen consumption. This reaction was intrinsic to the mesenteric circulation and not mediated by sympathetic nerves or central reflexes. Nonocclusive mesenteric ischemia in digitalized patients may reflect a similar abnormal response to the acute increases in portal pressure accompanying cardiac failure. |
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Authors:
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E H Kim; B L Gewertz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 5 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-30 Completed Date: 1987-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 382-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Digitalis* Digoxin / administration & dosage, adverse effects Homeostasis / drug effects Humans Intestine, Small / blood supply Ischemia / etiology Male Mesenteric Arteries / drug effects, physiology Mesenteric Veins / drug effects, physiology Oxygen Consumption / drug effects Plants, Medicinal* Plants, Toxic* Rats Rats, Inbred Strains Splanchnic Circulation / drug effects* Time Factors Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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