Document Detail


Chronic dietary restriction influences tumor metastasis in the rat: parametric considerations.
MedLine Citation:
PMID:  9290127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic dietary restriction is a well-documented means of inhibiting tumor growth. This study examines the effects of chronic dietary restriction on tumor metastasis in the rat. We investigate the effect of 1) the degree of food restriction, 2) the effect of preexposure to food restriction, and 3) the duration of food restriction after tumor inoculation on tumor metastasis. We also compare two methods of dietary restriction: 1) the time that food is available and 2) the amount of food available. Our findings demonstrate that rats restricted to 50% of ad libitum diet for one week before inoculation with MADB106 tumor cells and for three weeks after inoculation exhibit a significant (p < 0.001) reduction in lung colonization compared with animals fed ad libitum. Animals restricted to access to food for 4 hrs/day (60% of ad libitum) for the same period of time exhibit significantly (p < 0.005) greater lung tumor colonization than animals fed ad libitum. Preadaptation to the feeding regimen for one week before tumor inoculation proved to be critical in inhibiting tumor metastasis. The tumor-inhibitory effect was not significantly influenced by the duration of restriction after inoculation or by the manner in which food restriction was implemented. Finally, we demonstrate that inhibition of tumor colonization may be mediated by enhanced natural killer cell activity in the early postinoculation period.
Authors:
D M Hodgson; F Chiappelli; N S Morrow; A N Taylor
Related Documents :
11303467 - Energy expenditure of rats subjected to long-term food restriction.
9538327 - Effect of restricted nutrition on timing of puberty in female soay sheep.
1965567 - Modulation of free radicals and superoxide dismutases by age and dietary restriction.
16454857 - Quantitative genetics of larval life-history traits in rana temporaria in different env...
6619117 - Occurrence of four subunits in high molecular weight forms of polypeptide chain elongat...
9704987 - Amount of training affects associatively-activated event representation.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  28     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-17     Completed Date:  1997-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-98     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, School of Medicine, University of California Los Angeles 90095, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / chemically induced,  pathology*,  secondary
Analysis of Variance
Animals
Biological Assay
Body Weight / physiology*
Disease Models, Animal
Eating / physiology*
Food Deprivation / physiology
Killer Cells, Natural / physiology
Lung Neoplasms / pathology,  secondary*
Male
Random Allocation
Rats
Rats, Inbred F344
Spleen / cytology
Time Factors
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
4-784612-34323//PHS HHS; CA-16042/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Modulation of phase I and phase II xenobiotic-metabolizing enzymes by selenium-enriched garlic in ra...
Next Document:  Antitumor effect of an oral administration of canthaxanthin on BALB/c mice bearing thymoma cells.