Document Detail


Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury.
MedLine Citation:
PMID:  18356330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Consumption of flavonoid-rich foods and beverages is thought to reduce the risk of cardiovascular diseases. Whereas the biological activities of flavonoids have been characterized in vitro, there are no clear experimental data demonstrating that chronic dietary intake and intestinal absorption of flavonoids actually protects the heart against ischemia-reperfusion injury. We tested whether long-term consumption of specific flavonoids (anthocyanins) included in normal food could render the heart of rats more resistant to myocardial infarction. Maize kernels that differed specifically in their accumulation of anthocyanins were used to prepare rodent food in which anthocyanins were either present or absent. Male Wistar rats were fed the anthocyanin-rich (ACN-rich) or the anthocyanin-free (ACN-free) diet for a period of 8 wk. Anthocyanins were significantly absorbed and detected in the blood and urine of only rats fed the ACN-rich diet. In Langendorff preparations, the hearts of rats fed the ACN-rich diet were more resistant to regional ischemia and reperfusion insult. Moreover, on an in vivo model of coronary occlusion and reperfusion, infarct size was reduced in rats that ate the ACN-rich diet than in those that consumed the ACN-free diet (P < 0.01). Cardioprotection was associated with increased myocardial glutathione levels, suggesting that dietary anthocyanins might modulate cardiac antioxidant defenses. Our findings suggest important potential health benefits of foods rich in anthocyanins and emphasize the need to develop anthocyanin-rich functional foods with protective activities for promoting human health.
Authors:
Marie-Claire Toufektsian; Michel de Lorgeril; Norbert Nagy; Patricia Salen; Maria Benedetta Donati; Lucia Giordano; Hans-Peter Mock; Silke Peterek; Andrea Matros; Katia Petroni; Roberto Pilu; Domenico Rotilio; Chiara Tonelli; Joel de Leiris; François Boucher; Cathie Martin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  138     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  747-52     Citation Subset:  IM    
Affiliation:
Equipe PRETA-Coeur et Nutrition, TIMC-IMAG Unité Mixte de Recherche, Université Jospeh Fourier CNRS 5525, F-38000 Grenoble, France. marie-claire.toufektsian@ujf-grenoble.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthocyanins / administration & dosage*,  analysis,  genetics,  pharmacology*
Drug Administration Schedule
Gene Expression Regulation, Plant
Heart / drug effects*
Male
Myocardial Reperfusion Injury / prevention & control*
Myocardium / metabolism
Rats
Rats, Wistar
Zea mays / chemistry,  genetics,  metabolism
Chemical
Reg. No./Substance:
0/Anthocyanins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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